pch-2 Putative pachytene checkpoint protein 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pch-2
Official Full Name: Putative pachytene checkpoint protein 2
Primary source: WormBase:WBGene00008641
Locus tag: CELE_F10B5.5
See related: AllianceGenome:WB:WBGene00008641
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in meiotic recombination checkpoint signaling and reciprocal meiotic recombination. Located in kinetochore. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome 3. Orthologous to human TRIP13 (thyroid hormone receptor interactor 13). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pch-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (8158349..8159925)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The conserved AAA ATPase PCH-2 distributes its regulation of meiotic prophase events through multiple meiotic HORMADs in C. elegans.
Title: The conserved AAA ATPase PCH-2 distributes its regulation of meiotic prophase events through multiple meiotic HORMADs in C. elegans.
The conserved AAA-ATPase PCH-2 (TRIP13) regulates spindle checkpoint strength.
Title: The conserved AAA-ATPase PCH-2 (TRIP13) regulates spindle checkpoint strength.
PCH-2 collaborates with CMT-1 to proofread meiotic homolog interactions.
Title: PCH-2 collaborates with CMT-1 to proofread meiotic homolog interactions.
The ability of TRIP13(PCH-2) to disassemble a p31(comet)/Mad2 complex.
Title: TRIP13PCH-2 promotes Mad2 localization to unattached kinetochores in the spindle checkpoint response.
PCH-2 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching.
Title: TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching.
Suggest pch-2 gene involved in lifespan determination in Caenorhabditis elegans.
Title: PCH-2 regulates Caenorhabditis elegans lifespan.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F10B5.5 (e-PCR)
- UniSTS:307450

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic recombination checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Putative pachytene checkpoint protein 2

NP_495711.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8158349..8159925

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063310.9 → NP_495711.1 Putative pachytene checkpoint protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495711.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09535

Conserved Domains (2) summary

COG0464
Location:5 → 418

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

cd19508
Location:121 → 319

RecA-like_Pch2-like; ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains