cyc-2.1 Cytochrome c 2.1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cyc-2.1
Official Full Name: Cytochrome c 2.1
Primary source: WormBase:WBGene00017121
Locus tag: CELE_E04A4.7
See related: AllianceGenome:WB:WBGene00017121
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables electron transfer activity. Involved in electron transport chain. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex. Predicted to be active in mitochondrial intermembrane space. Is expressed in body wall musculature; excretory cell; intestinal cell; nervous system; and pharynx. Human ortholog(s) of this gene implicated in cholangiocarcinoma; lung non-small cell carcinoma; pancreatic cancer; and thrombocytopenia. Orthologous to human CYCS (cytochrome c, somatic). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cyc-2.1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 2

Sequence:: Chromosome: IV; NC_003282.8 (4747904..4748449, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct peroxidase activities of CYC-2.1 and CYC-2.2 in the presence of cardiolipin arise from differences in the local heme environments.
Title: Recombinant expression, biophysical characterization, and cardiolipin-induced changes of two Caenorhabditis elegans cytochrome c proteins.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

E04A4.8 (e-PCR)
- UniSTS:316510

E04A4.7 (e-PCR)
- UniSTS:320494

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables electron transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables electron transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables electron transfer activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IC Inferred by Curator more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in electron transport chain	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial electron transport, cytochrome c to oxygen	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex	IC Inferred by Curator more info	PubMed
part_of respiratory chain complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cytochrome c 2.1

NP_001370630.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

4747904..4748449 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383085.2 → NP_001370630.1 Cytochrome c 2.1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O44479, P19974

Conserved Domains (1) summary

cl21467
Location:3 → 109

Cytochrom_C; Cytochrome c