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    glit-1 Neuroligin-like protein glit-1 [ Caenorhabditis elegans ]

    Gene ID: 180747, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glit-1
    Official Full Name
    Neuroligin-like protein glit-1
    Primary source
    WormBase:WBGene00018878
    Locus tag
    CELE_F55D10.3
    See related
    AllianceGenome:WB:WBGene00018878
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable neurexin family protein binding activity and signaling receptor activity. Involved in cellular response to paraquat and negative regulation of response to oxidative stress. Predicted to be located in presynapse. Predicted to be active in cell surface; plasma membrane; and synapse. Is expressed in dopaminergic neurons; head; intestine; and pharynx. Used to study Parkinson's disease. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See glit-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (4712279..4715080)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Palmitoyltransferase Neighboring gene J domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein uL23A Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans cysteine-string protein homologue DNJ-14 is dispensable for neuromuscular junction maintenance across ageing. Mulcahy B, et al. J Exp Biol, 2019 Nov 25. PMID 31624097
    2. Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment. Offenburger SL, et al. PLoS Genet, 2018 Jan. PMID 29346364, Free PMC Article
    3. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the neuroligin-like GLIT-1, the canonical apoptosis pathway and the calreticulin CRT-1 are required to prevent 6-OHDA-induced dopaminergic neurodegeneration.
      Title: Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cellular response to paraquat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Neuroligin-like protein glit-1
    NP_508807.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4712279..4715080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076406.8 → NP_508807.1  Neuroligin-like protein glit-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508807.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20826
      Conserved Domains (1) summary
      pfam00135
      Location:56 → 629
      COesterase; Carboxylesterase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20826.1

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