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    pnk-4 4'-phosphopantetheine phosphatase [ Caenorhabditis elegans ]

    Gene ID: 180779, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pnk-4
    Official Full Name
    4'-phosphopantetheine phosphatase
    Primary source
    WormBase:WBGene00006862
    Locus tag
    CELE_C42D8.3
    See related
    AllianceGenome:WB:WBGene00006862
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable pantothenate kinase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including intestine; nervous system; non-striated muscle; pharynx; and tail. Human ortholog(s) of this gene implicated in cataract. Orthologous to human PANK4 (pantothenate kinase 4 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pnk-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (5087841..5092538)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ETS domain-containing protein;ETS domain-containing transcription factor ets-5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Ile Neighboring gene Inactive angiotensin-converting enzyme-related protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of regions of the Caenorhabditis elegans X chromosome containing vitellogenin genes. Heine U, et al. J Mol Biol, 1986 Apr 5. PMID 3735423
    2. Spatial single-cell sequencing of meiosis I arrested oocytes indicates acquisition of maternal transcripts from the soma. Trimmer KA, et al. Cell Rep, 2023 Jun 27. PMID 37227820, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pantothenate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pantothenate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in coenzyme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    4'-phosphopantetheine phosphatase
    NP_508866.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5087841..5092538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076465.5 → NP_508866.1  4'-phosphopantetheine phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508866.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18580
      Conserved Domains (2) summary
      pfam03630
      Location:23 → 345
      Fumble; Fumble
      cl15397
      Location:422 → 739
      DUF89; Protein of unknown function DUF89
    Nucleotide Protein
    Heading Accession and Version

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