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    Naxd NAD(P)HX dehydratase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40085, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Naxdprovided by FlyBase
    Official Full Name
    NAD(P)HX dehydrataseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036848
    Locus tag
    Dmel_CG10424
    See related
    AllianceGenome:FB:FBgn0036848
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10424; Dmel\CG10424
    Summary
    Predicted to enable ATP-dependent NAD(P)H-hydrate dehydratase activity. Predicted to be involved in metabolite repair. Predicted to be located in cytosol and mitochondrion. Is expressed in adult head; embryonic/larval midgut; and organism. Orthologous to human NAXD (NAD(P)HX dehydratase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Naxd in Genome Data Viewer
    Location:
    75F7-75F7; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19096399..19097709, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19089499..19090809, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Misexpression suppressor of ras 6 Neighboring gene Canopy b Neighboring gene uncharacterized protein Neighboring gene Gemin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Combining mapping and arraying: An approach to candidate gene identification. Wayne ML, et al. Proc Natl Acad Sci U S A, 2002 Nov 12. PMID 12415114, Free PMC Article
    2. FoxO suppresses endoplasmic reticulum stress to inhibit growth of Tsc1-deficient tissues under nutrient restriction. Gupta A, et al. Elife, 2020 Jun 11. PMID 32525804, Free PMC Article
    3. Comparative Genomic Analyses Provide New Insights into the Evolutionary Dynamics of Heterochromatin in Drosophila. Caizzi R, et al. PLoS Genet, 2016 Aug. PMID 27513559, Free PMC Article
    4. Hematopoietic plasticity mapped in Drosophila and other insects. Hultmark D, et al. Elife, 2022 Aug 3. PMID 35920811, Free PMC Article
    5. Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila. Cho B, et al. Nat Commun, 2020 Sep 8. PMID 32900993, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP-dependent NAD(P)H-hydrate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent NAD(P)H-hydrate dehydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydro-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in metabolite repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metabolite repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NAD(P)HX dehydratase
    Names
    CG10424-PA
    Naxd-PA
    NP_649090.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19096399..19097709 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140833.3 → NP_649090.1  NAD(P)HX dehydratase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649090.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVW8
      Related
      FBpp0074800
      Conserved Domains (1) summary
      cd01171
      Location:28 → 287
      YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVW8.1 Q9VVW8

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