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    zfr-1 DZF domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 190806, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zfr-1
    Official Full Name
    DZF domain-containing protein
    Primary source
    WormBase:WBGene00022388
    Locus tag
    CELE_Y95B8A.8
    See related
    AllianceGenome:WB:WBGene00022388
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable double-stranded RNA binding activity and single-stranded RNA binding activity. Acts upstream of or within with a positive effect on axon guidance. Predicted to be part of spliceosomal complex. Orthologous to several human genes including ZFR (zinc finger RNA binding protein) and ZFR2 (zinc finger RNA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See zfr-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    13
    Sequence:
    Chromosome: I; NC_003279.8 (853451..872827)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Sperm mitochondrial-associated cysteine-rich protein-like Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-6 Neighboring gene Bursicon;Bursicon subunit alpha;Secreted protein Neighboring gene FBD domain-containing protein Neighboring gene Guanine nucleotide-binding protein alpha-16 subunit Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The zinc finger RNA binding protein, ZFR, contributes to axon guidance in Caenorhabditis elegans. Kjærgaard T, et al. Gene, 2015 Feb 15. PMID 25476027
    2. The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription. Cecere G, et al. Mol Cell, 2013 Jun 27. PMID 23806335, Free PMC Article
    3. Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126). Schmitz C, et al. Proc Natl Acad Sci U S A, 2007 Jan 16. PMID 17213328, Free PMC Article
    4. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    5. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within_positive_effect axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		  
    acts_upstream_of_or_within_positive_effect neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DZF domain-containing protein
    NP_490785.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      853451..872827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058384.5 → NP_490785.3  DZF domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490785.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      E9RKC7
      Conserved Domains (4) summary
      smart00572
      Location:481 → 720
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      smart00451
      Location:125 → 157
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:129 → 151
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:175 → 198
      zf-met; Zinc-finger of C2H2 type
    Nucleotide Protein
    Heading Accession and Version

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