F49B2.6 Aminopeptidase [Caenorhabditis elegans] - Gene

Summary

Official Symbol: F49B2.6
Official Full Name: Aminopeptidase
Primary source: WormBase:WBGene00009865
Locus tag: CELE_F49B2.6
See related: AllianceGenome:WB:WBGene00009865
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Human ortholog(s) of this gene implicated in cervix carcinoma and type 2 diabetes mellitus. Orthologous to several human genes including ERAP1 (endoplasmic reticulum aminopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

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Function	Evidence Code	Pubs
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in peptide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_493503.2

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The following sections contain reference sequences that belong to a specific genome build. Explain