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    Cyp6u1 Cytochrome P450 6u1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35608, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp6u1provided by FlyBase
    Official Full Name
    Cytochrome P450 6u1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033121
    Locus tag
    Dmel_CG3567
    See related
    AllianceGenome:FB:FBgn0033121
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    6u1; CG3567; Dmel\CG3567
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; gonad; and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp6u1 in Genome Data Viewer
    Location:
    42E1-42E1; 2-55 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6971996..6975026, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2859501..2862531, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene missing-in-metastasis Neighboring gene Chemosensory protein B 42c Neighboring gene Chemosensory protein B 42a Neighboring gene pickpocket 25 Neighboring gene long non-coding RNA:CR44170 Neighboring gene long non-coding RNA:CR44171 Neighboring gene UFM1 specific peptidase 1 Neighboring gene visceral mesodermal armadillo-repeats

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Male specific expression of a cytochrome P450 (Cyp312a1) in Drosophila melanogaster. Kasai S, et al. Biochem Biophys Res Commun, 2003 Jan 24. PMID 12559957
    2. Genetic characterization of the Drosophila homologue of coronin. Bharathi V, et al. J Cell Sci, 2004 Apr 15. PMID 15090595
    3. Rethinking the ecdysteroid source during Drosophila pupal-adult development. Scanlan JL, et al. Insect Biochem Mol Biol, 2023 Jan. PMID 36481381
    4. Cadmium-induced genome-wide DNA methylation changes in growth and oxidative metabolism in Drosophila melanogaster. Guan DL, et al. BMC Genomics, 2019 May 9. PMID 31072326, Free PMC Article
    5. A Drosophila DEG/ENaC channel subunit is required for male response to female pheromones. Lin H, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16129837, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Additionally, RNA interference against RG-enriched cytochrome p450s Cyp6u1 and Cyp6g2 produced a lethal ecdysone deficiency and a juvenile hormone deficiency, respectively, flagging a critical role for these genes in hormone synthesis.
      Title: Transcriptome Analysis of Drosophila melanogaster Third Instar Larval Ring Glands Points to Novel Functions and Uncovers a Cytochrome p450 Required for Development.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 6u1
    Names
    CG3567-PA
    CG3567-PB
    CG3567-PC
    Cyp6u1-PA
    Cyp6u1-PB
    Cyp6u1-PC
    cytochrome P450
    NP_001286149.1
    NP_001286150.1
    NP_610252.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6971996..6975026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299221.1 → NP_001286150.1  cytochrome P450 6u1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286150.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T9B9, Q9V979
      UniProtKB/TrEMBL
      A0A0B4LET2
      Conserved Domains (1) summary
      cl12078
      Location:38 → 475
      p450; Cytochrome P450

    2. NM_136408.4 → NP_610252.3  cytochrome P450 6u1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610252.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T9B9, Q9V979
      UniProtKB/TrEMBL
      A0A0B4LET2
      Related
      FBpp0085516
      Conserved Domains (1) summary
      cl12078
      Location:38 → 475
      p450; Cytochrome P450

    3. NM_001299220.1 → NP_001286149.1  cytochrome P450 6u1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286149.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T9B9, Q9V979
      UniProtKB/TrEMBL
      A0A0B4LET2
      Conserved Domains (1) summary
      cl12078
      Location:38 → 475
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LET2 A0A0B4LET2
    Q9V979.3 Q9V979

    Gene LinkOut

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