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    kek1 kekkon 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34688, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kek1provided by FlyBase
    Official Full Name
    kekkon 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0015399
    Locus tag
    Dmel_CG12283
    See related
    AllianceGenome:FB:FBgn0015399
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GM02380; CG12283; CT18186; Dmel\CG12283; Dmkek1; GM02380; kek; Kek; kek-1; Kek-1; Kek1; KEK1; kekon; l(2)01433; n(2)k07332; NB1; SD01674; uns
    Summary
    Enables epidermal growth factor receptor binding activity and signaling receptor inhibitor activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway and oogenesis. Located in apical plasma membrane. Is expressed in several structures, including cuboidal/columnar epithelium; follicle cell; imaginal disc; larval midline neurons; and peripheral nervous system. Orthologous to human LRRC24 (leucine rich repeat containing 24). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kek1 in Genome Data Viewer
    Location:
    34A1-34A1; 2-47 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12817000..12822787, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12817000..12822787, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long noncoding RNA: testis-specific 9 Neighboring gene long non-coding RNA:CR43818 Neighboring gene long non-coding RNA:CR44970 Neighboring gene long non-coding RNA:CR44971

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Slit branches out: a secreted protein mediates both attractive and repulsive axon guidance. Zinn K, et al. Cell, 1999 Apr 2. PMID 10199395
    2. The Drosophila kekkon genes: novel members of both the leucine-rich repeat and immunoglobulin superfamilies expressed in the CNS. Musacchio M, et al. Dev Biol, 1996 Aug 25. PMID 8812109
    3. Quantitative analysis of the GAL4/UAS system in Drosophila oogenesis. Goentoro LA, et al. Genesis, 2006 Feb. PMID 16425298
    4. Control of bract formation in Drosophila: poxn, kek1, and the EGF-R pathway. Layalle S, et al. Genesis, 2004 Aug. PMID 15286997
    5. Knockouts of Kekkon1 define sequence elements essential for Drosophila epidermal growth factor receptor inhibition. Alvarado D, et al. Genetics, 2004 Jan. PMID 15020418, Free PMC Article

    See all (136) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kek1 inhibits EGFR activity during eye development
      Title: Knockouts of Kekkon1 define sequence elements essential for Drosophila epidermal growth factor receptor inhibition.
    2. kek1 can suppress bract formation and can interfere with other steps of sensory development, including Sensory Mother Cell determination and shaft differentiation.
      Title: Control of bract formation in Drosophila: poxn, kek1, and the EGF-R pathway.
    3. the leucine-rich repeats of Kek1 in conjunction with its juxta/transmembrane region direct association and inhibition of the Drosophila EGFR through interactions with receptor domain V
      Title: Bipartite inhibition of Drosophila epidermal growth factor receptor by the extracellular and transmembrane domains of Kekkon1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kekkon 1
    Names
    CG12283-PB
    CG12283-PC
    Kekkon1
    Kekon-1
    kek1-PB
    kek1-PC
    kekkon
    kekkon-1
    kekkonI
    unstrung

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12817000..12822787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078835.3 → NP_523559.3  kekkon 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523559.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      L7XBB4, P91643, Q9VK54
      Conserved Domains (6) summary
      cd00096
      Location:346 → 426
      Ig; Immunoglobulin domain
      smart00082
      Location:277 → 327
      LRRCT; Leucine rich repeat C-terminal domain
      smart00410
      Location:338 → 429
      IG_like; Immunoglobulin like
      cd00116
      Location:119 → 277
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:103 → 122
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:148 → 207
      LRR_8; Leucine rich repeat

    2. NM_001316391.1 → NP_001303320.1  kekkon 1, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      L7XBB4, P91643, Q9VK54
      Conserved Domains (6) summary
      cd00096
      Location:346 → 426
      Ig; Immunoglobulin domain
      smart00082
      Location:277 → 327
      LRRCT; Leucine rich repeat C-terminal domain
      smart00410
      Location:338 → 429
      IG_like; Immunoglobulin like
      cd00116
      Location:119 → 277
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:103 → 122
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:148 → 207
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91643 P91643
    Q2XY32 Q2XY32
    Q8T3J2 Q8T3J2
    Q9VK54 Q9VK54

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