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    CG7430 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39988, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CG7430provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036762
    Locus tag
    Dmel_CG7430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG7430; E3
    Orthologs
    all
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    Genomic context

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    See CG7430 in Genome Data Viewer
    Location:
    75A4-75A4; 3-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17846916..17849601)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17840016..17842701)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45175 Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 19 Neighboring gene Tryptophanyl-tRNA synthetase, mitochondrial Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. Friedman AA, et al. Sci Signal, 2011 Oct 25. PMID 22028469, Free PMC Article
    2. In vivo proximity biotin ligation identifies the interactome of Egalitarian, a Dynein cargo adaptor. Baker FC, et al. Development, 2021 Nov 15. PMID 35020877, Free PMC Article
    3. In vivo profiling of the Zucchini proximal proteome in the Drosophila ovary. Nguyen TTM, et al. Development, 2023 Feb 15. PMID 36762624
    4. Protein interaction mapping: a Drosophila case study. Formstecher E, et al. Genome Res, 2005 Mar. PMID 15710747, Free PMC Article
    5. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dihydrolipoyl dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oxoglutarate dehydrogenase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7430-PA
    CG7430-PB
    alpha-ketoglutarate dehydrogenase
    alpha-ketoglutarate dehydrogenase E3 subunit
    pyruvate dehydrogenase E3 subunit
    NP_001262000.1
    NP_649017.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17846916..17849601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140760.4 → NP_649017.1  uncharacterized protein Dmel_CG7430, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649017.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVL7
      Related
      FBpp0074906
      Conserved Domains (4) summary
      PRK06327
      Location:35 → 504
      PRK06327; dihydrolipoamide dehydrogenase; Validated
      pfam00070
      Location:211 → 290
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:385 → 491
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
      cl21454
      Location:35 → 74
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001275071.1 → NP_001262000.1  uncharacterized protein Dmel_CG7430, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262000.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVL7
      Conserved Domains (4) summary
      PRK06327
      Location:35 → 504
      PRK06327; dihydrolipoamide dehydrogenase; Validated
      pfam00070
      Location:211 → 290
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:385 → 491
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
      cl21454
      Location:35 → 74
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVL7 Q9VVL7

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