adpr-1 WD and tetratricopeptide repeats protein 1;WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: adpr-1
Official Full Name: WD and tetratricopeptide repeats protein 1;WD_REPEATS_REGION domain-containing protein
Primary source: WormBase:WBGene00044440
Locus tag: CELE_Y73E7A.9
See related: AllianceGenome:WB:WBGene00044440
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in negative regulation of fatty acid biosynthetic process. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Used to study obesity. Orthologous to human WDTC1 (WD and tetratricopeptide repeats 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See adpr-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (1610390..1621335)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in negative regulation of fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD and tetratricopeptide repeats protein 1;WD_REPEATS_REGION domain-containing protein

NP_001021829.1

Confirmed by transcript evidence

NP_001293408.1

Confirmed by transcript evidence

NP_001293409.1

Confirmed by transcript evidence

NP_001293410.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

1610390..1621335

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026658.2 → NP_001021829.1 WD and tetratricopeptide repeats protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021829.1

Status: REVIEWED

UniProtKB/TrEMBL

Q4W5Q8

Conserved Domains (3) summary

sd00006
Location:285 → 310

TPR; TPR repeat [structural motif]

sd00039
Location:45 → 80

7WD40; WD40 repeat [structural motif]

cl29593
Location:37 → 201

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001306479.3 → NP_001293408.1 WD and tetratricopeptide repeats protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293408.1

Status: REVIEWED

UniProtKB/TrEMBL

W6RQR8

Conserved Domains (2) summary

sd00006
Location:77 → 102

TPR; TPR repeat [structural motif]

cl29593
Location:228 → 299

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001306480.3 → NP_001293409.1 WD and tetratricopeptide repeats protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293409.1

Status: REVIEWED

UniProtKB/TrEMBL

W6RXS5

Conserved Domains (2) summary

sd00006
Location:26 → 51

TPR; TPR repeat [structural motif]

cl29593
Location:177 → 248

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001306481.3 → NP_001293410.1 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293410.1

Status: REVIEWED

UniProtKB/TrEMBL

W6RRQ3

Conserved Domains (1) summary

cl29593
Location:61 → 132

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...