src-1 Tyrosine protein-kinase src-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: src-1
Official Full Name: Tyrosine protein-kinase src-1
Primary source: WormBase:WBGene00005077
Locus tag: CELE_Y92H12A.1
See related: AllianceGenome:WB:WBGene00005077
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables netrin receptor binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including axis specification; commissural neuron axon guidance; and embryonic morphogenesis. Located in contractile muscle fiber and phagocytic cup. Is expressed in several structures, including anchor cell; anus; distal tip cell; head neurons; and vulval cell. Used to study Goldenhar syndrome. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer (multiple); diabetes mellitus (multiple); ductal carcinoma in situ; immunodeficiency 22; and systemic lupus erythematosus. Orthologous to several human genes including FYN (FYN proto-oncogene, Src family tyrosine kinase); SRC (SRC proto-oncogene, non-receptor tyrosine kinase); and YES1 (YES proto-oncogene 1, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See src-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (1567602..1580208)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SRC-1 controls growth cone polarity and protrusion with the UNC-6/Netrin receptor UNC-5 in Caenorhabditis elegans.
Title: SRC-1 controls growth cone polarity and protrusion with the UNC-6/Netrin receptor UNC-5 in Caenorhabditis elegans.
Data indicate that a positive correlation between SRC-1 and the on-rate of PAR-2 is the essential mechanism underlying polarity reversal.
Title: Positioning of polarity formation by extracellular signaling during asymmetric cell division.
Data suggest that MIG-13 controls anteroposterior cell migration by interacting with UNC-71 and SRC-1 in C. elegans.
Title: MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans.
identify an essential role of the nonreceptor tyrosine kinase SRC-1 in INA-1-mediated cell corpse removal
Title: Engulfment of apoptotic cells in C. elegans is mediated by integrin alpha/SRC signaling.
Src and Wnt signaling regulate dynactin accumulation to the P2-EMS cell border in C. elegans embryos
Title: Src and Wnt signaling regulate dynactin accumulation to the P2-EMS cell border in C. elegans embryos.
These results suggest that SRC-1 and KIN-22 play distinct roles under the control of CSK-1.
Title: Distinct roles of the Src family kinases, SRC-1 and KIN-22, that are negatively regulated by CSK-1 in C. elegans.
SRC-1 functions in responding to various extracellular guidance cues that direct the cell migration via disparate signaling pathways in different cell types.
Title: SRC-1, a non-receptor type of protein tyrosine kinase, controls the direction of cell and growth cone migration in C. elegans.
SRC-1 is required for UNC-5-induced axon repulsion and gonad migration signaling pathways and in which localizing SRC-1 activity to UNC-5 is crucial for proper signal transduction in response to unc-6/netrin.
Title: SRC-1 mediates UNC-5 signaling in Caenorhabditis elegans.
Data show that the asymmetry of GPR-1/2 (which act with GOA-1 and GPA-16) localization depends on PAR-3 and its downstream intermediate LET-99, as well as on the MES-1/SRC-1 signaling pathway.
Title: LET-99 opposes Galpha/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables netrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anterior/posterior axis specification, embryo	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in commissural neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic digestive tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of mitotic spindle orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gonad morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in left/right axis specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in netrin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in contractile muscle fiber	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic cup	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic cup	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Tyrosine protein-kinase src-1

NP_001293421.1

Confirmed by transcript evidence

NP_001293422.1

Confirmed by transcript evidence

NP_001364774.1

Confirmed by transcript evidence

NP_001364829.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

1567602..1580208

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001377653.2 → NP_001364774.1 Tyrosine protein-kinase src-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EE56, W6RRW6, W6RTE9, W6SBD5

Conserved Domains (3) summary

cd09933
Location:134 → 236

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd11845
Location:75 → 126

SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases

cd05034
Location:266 → 518

PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
NM_001377652.2 → NP_001364829.1 Tyrosine protein-kinase src-1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

cd09933
Location:138 → 240

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd11845
Location:79 → 130

SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases

cd05034
Location:270 → 522

PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
NM_001306492.4 → NP_001293421.1 Tyrosine protein-kinase src-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293421.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EE56

Conserved Domains (4) summary

cd09933
Location:78 → 180

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd11845
Location:19 → 70

SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases

cd05034
Location:210 → 462

PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases

pfam07714
Location:206 → 461

Pkinase_Tyr; Protein tyrosine kinase
NM_001306493.3 → NP_001293422.1 Tyrosine protein-kinase src-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293422.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EE56

Conserved Domains (2) summary

pfam07714
Location:1 → 209

Pkinase_Tyr; Protein tyrosine kinase

cl21453
Location:1 → 210

PKc_like; Protein Kinases, catalytic domain