fasn-1 Fatty acid synthase [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: fasn-1
Official Full Name: Fatty acid synthase
Primary source: WormBase:WBGene00009342
Locus tag: CELE_F32H2.5
See related: AllianceGenome:WB:WBGene00009342
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable fatty acid synthase activity. Predicted to be involved in fatty acid biosynthetic process. Is expressed in excretory duct; hermaphrodite gonad; hypodermis; intestine; and neurons. Used to study muscular disease. Orthologous to human FASN (fatty acid synthase). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See fasn-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 11

Sequence:: Chromosome: I; NC_003279.8 (8975366..8986540, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proteolytic activation of fatty acid synthase signals pan-stress resolution.
Title: Proteolytic activation of fatty acid synthase signals pan-stress resolution.
Fatty acid synthase (FAS) gene, encoding for a key enzyme involved in the biogenesis of membrane lipids in rapidly proliferating cells, is a conserved target of the p53 family throughout the evolution.
Title: The fatty acid synthase gene is a conserved p53 family target from worm to human.
Fasn-1 regulates antimicrobial peptide nlp-29 expression in a WNK-1 and gck-3 dependent manner.
Title: The fatty acid synthase fasn-1 acts upstream of WNK and Ste20/GCK-VI kinases to modulate antimicrobial peptide expression in C. elegans epidermis.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

F32H2.5 (e-PCR)
- UniSTS:306211

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	IEA Inferred from Electronic Annotation more info
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity	IEA Inferred from Electronic Annotation more info
enables [acyl-carrier-protein] S-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables enoyl-[acyl-carrier-protein] reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables fatty acid synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid synthase activity	IEA Inferred from Electronic Annotation more info
enables fatty acyl-[ACP] hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables phosphopantetheine binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Fatty acid synthase

NP_492417.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8975366..8986540 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060016.8 → NP_492417.2 Fatty acid synthase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492417.2

Status: REVIEWED

UniProtKB/TrEMBL

P91871

Conserved Domains (9) summary

cd08954
Location:1968 → 2204

KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs

smart00829
Location:1654 → 1946

PKS_ER; Enoylreductase

cd00833
Location:38 → 440

PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...

pfam16197
Location:398 → 507

KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension

pfam00550
Location:2219 → 2284

PP-binding; Phosphopantetheine attachment site

cl00509
Location:892 → 1104

hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...

cl08282
Location:533 → 852

Acyl_transf_1; Acyl transferase domain

cl21454
Location:1406 → 1602

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

cl21494
Location:2385 → 2444

Abhydrolase; alpha/beta hydrolases