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    ptr-2 SSD domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171950, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ptr-2
    Official Full Name
    SSD domain-containing protein
    Primary source
    WormBase:WBGene00004217
    Locus tag
    CELE_C32E8.8
    See related
    AllianceGenome:WB:WBGene00004217
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transmembrane transporter activity. Involved in mitotic cytokinesis and molting cycle. Acts upstream of or within nematode male tail mating organ morphogenesis. Predicted to be located in membrane. Predicted to be active in cytoplasmic vesicle membrane and plasma membrane. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human PTCHD1 (patched domain containing 1) and PTCHD4 (patched domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ptr-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (3789309..3792797, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Tubulin polymerization-promoting protein homolog Neighboring gene Large ribosomal subunit protein eL13 Neighboring gene Ethylmalonyl-CoA decarboxylase Neighboring gene RING-type domain-containing protein Neighboring gene Phosphatidylinositol-binding clathrin assembly protein unc-11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A C. elegans patched gene, ptc-1, functions in germ-line cytokinesis. Kuwabara PE, et al. Genes Dev, 2000 Aug 1. PMID 10921907, Free PMC Article
    2. The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo. Baugh LR, et al. Development, 2005 Apr. PMID 15772128
    3. Changes in Nuclear Receptor and Vitellogenin Gene Expression in Response to Steroids and Heavy Metal in Caenorhabditis elegans. Novillo A, et al. Integr Comp Biol, 2005 Jan. PMID 21676746
    4. Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution. Tischler J, et al. Genome Biol, 2006. PMID 16884526, Free PMC Article
    5. Allelic ratios and the mutational landscape reveal biologically significant heterozygous SNVs. Chu JS, et al. Genetics, 2012 Apr. PMID 22267497, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in molting cycle, collagen and cuticulin-based cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in molting cycle, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nematode male tail mating organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SSD domain-containing protein
    NP_491221.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3789309..3792797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058820.5 → NP_491221.1  SSD domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491221.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91129
      Conserved Domains (1) summary
      pfam02460
      Location:47 → 858
      Patched; Patched family
    Nucleotide Protein
    Heading Accession and Version

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