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    acox-1.2 Acyl-coenzyme A oxidase acox-1.2 [ Caenorhabditis elegans ]

    Gene ID: 173163, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acox-1.2
    Official Full Name
    Acyl-coenzyme A oxidase acox-1.2
    Primary source
    WormBase:WBGene00008565
    Locus tag
    CELE_F08A8.2
    See related
    AllianceGenome:WB:WBGene00008565
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ATP binding activity and acyl-CoA oxidase activity. Involved in ascaroside biosynthetic process and fatty acid beta-oxidation using acyl-CoA oxidase. Predicted to be active in peroxisome. Is expressed in intestine. Human ortholog(s) of this gene implicated in Mitchell syndrome; congenital bile acid synthesis defect 6; and peroxisomal acyl-CoA oxidase deficiency. Orthologous to several human genes including ACOX1 (acyl-CoA oxidase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acox-1.2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (12942280..12946588)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ENTH domain-containing protein Neighboring gene Acyl-coenzyme A oxidase acox-1.1 Neighboring gene Acyl-coenzyme A oxidase acox-1.3 Neighboring gene Acyl-coenzyme A oxidase acox-1.4 Neighboring gene DUF2857 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural characterization of acyl-CoA oxidases reveals a direct link between pheromone biosynthesis and metabolic state in Caenorhabditis elegans. Zhang X, et al. Proc Natl Acad Sci U S A, 2016 Sep 6. PMID 27551084, Free PMC Article
    2. Acyl-CoA oxidase complexes control the chemical message produced by Caenorhabditis elegans. Zhang X, et al. Proc Natl Acad Sci U S A, 2015 Mar 31. PMID 25775534, Free PMC Article
    3. The metabolite alpha-ketobutyrate extends lifespan by promoting peroxisomal function in C. elegans. Wu N, et al. Nat Commun, 2023 Jan 16. PMID 36646719, Free PMC Article
    4. Acyl-CoA Oxidases Fine-Tune the Production of Ascaroside Pheromones with Specific Side Chain Lengths. Zhang X, et al. ACS Chem Biol, 2018 Apr 20. PMID 29537254
    5. Chemical Signaling Regulates Axon Regeneration via the GPCR-Gqα Pathway in Caenorhabditis elegans. Shimizu T, et al. J Neurosci, 2022 Feb 2. PMID 34862187, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural characterization of ACOX-1.1 and ACOX-1.2 reveals a direct link between pheromone biosynthesis and metabolic state in Caenorhabditis elegans.
      Title: Structural characterization of acyl-CoA oxidases reveals a direct link between pheromone biosynthesis and metabolic state in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyl-CoA oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyl-CoA oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acyl-CoA oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ascaroside biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ascaroside biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ascaroside biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Acyl-coenzyme A oxidase acox-1.2
    NP_493262.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      12942280..12946588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060861.6 → NP_493262.2  Acyl-coenzyme A oxidase acox-1.2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493262.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62137
      Conserved Domains (1) summary
      cl09933
      Location:12 → 635
      ACAD; Acyl-CoA dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O62137.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.