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    ard-1 3-hydroxyacyl-CoA dehydrogenase;3-hydroxyacyl-CoA dehydrogenase type-2 [ Caenorhabditis elegans ]

    Gene ID: 178016, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ard-1
    Official Full Name
    3-hydroxyacyl-CoA dehydrogenase;3-hydroxyacyl-CoA dehydrogenase type-2
    Primary source
    WormBase:WBGene00000181
    Locus tag
    CELE_F01G4.2
    See related
    AllianceGenome:WB:WBGene00000181
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Predicted to be involved in androgen metabolic process; estrogen metabolic process; and fatty acid metabolic process. Predicted to be active in mitochondrion. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in pheochromocytoma and syndromic X-linked intellectual disability type 10. Orthologous to human HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ard-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (11131279..11133805)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Endoplasmin homolog Neighboring gene DNA topoisomerase (ATP-hydrolyzing);Meiotic recombination protein spo-11 Neighboring gene SWI/SNF chromatin remodeling complex core catalytic subunit swsn-4 Neighboring gene Helicase SKI2W Neighboring gene ncRNA Neighboring gene CNH domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of Caenorhabditis elegans pry-1/Axin suppressors identifies genes involved in reproductive structure development, stress responses, and aging. Mallick A, et al. G3 (Bethesda), 2022 Feb 4. PMID 35100345, Free PMC Article
    2. ADAR-mediated regulation of PQM-1 expression in neurons impacts gene expression throughout C. elegans and regulates survival from hypoxia. Mahapatra A, et al. PLoS Biol, 2023 Sep. PMID 37747897, Free PMC Article
    3. Xenobiotic detoxification in the nematode Caenorhabditis elegans. Lindblom TH, et al. J Exp Zool A Comp Exp Biol, 2006 Sep 1. PMID 16902959, Free PMC Article
    4. Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms. Srinivasan S, et al. Cell Metab, 2008 Jun. PMID 18522834, Free PMC Article
    5. Proteomic analysis of protein expression profiles during Caenorhabditis elegans development using two-dimensional difference gel electrophoresis. Tabuse Y, et al. Proteomics, 2005 Jul. PMID 15996007

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in androgen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in estrogen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    3-hydroxyacyl-CoA dehydrogenase;3-hydroxyacyl-CoA dehydrogenase type-2
    NP_001293993.1
    • Confirmed by transcript evidence
    NP_502083.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11131279..11133805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069682.8 → NP_502083.1  3-hydroxyacyl-CoA dehydrogenase type-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502083.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19102
      Conserved Domains (2) summary
      cd05371
      Location:8 → 258
      HSD10-like_SDR_c; 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs
      PRK05557
      Location:6 → 257
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated

    2. NM_001307064.3 → NP_001293993.1  3-hydroxyacyl-CoA dehydrogenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293993.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AD09
      Conserved Domains (1) summary
      cl21454
      Location:1 → 84
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version

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