U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    che-6 Cyclic nucleotide-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 182823, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    che-6
    Official Full Name
    Cyclic nucleotide-binding domain-containing protein
    Primary source
    WormBase:WBGene00000487
    Locus tag
    CELE_C23H5.7
    See related
    AllianceGenome:WB:WBGene00000487
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cGMP binding activity; intracellularly cAMP-activated cation channel activity; and intracellularly cGMP-activated cation channel activity. Predicted to be involved in monoatomic cation transmembrane transport. Located in neuronal cell body. Is expressed in ASEL; ASER; AWCL; and AWCR. Human ortholog(s) of this gene implicated in achromatopsia 2; color blindness; retinitis pigmentosa; and retinitis pigmentosa 49. Orthologous to several human genes including CNGA1 (cyclic nucleotide gated channel subunit alpha 1); CNGA2 (cyclic nucleotide gated channel subunit alpha 2); and CNGA3 (cyclic nucleotide gated channel subunit alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See che-6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    13
    Sequence:
    Chromosome: IV; NC_003282.8 (2104056..2111408, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Carbon storage regulator;G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene BURP domain-containing protein;Reelin domain-containing protein;Uncharacterized protein Neighboring gene DUF3719 domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cell- and subunit-specific mechanisms of CNG channel ciliary trafficking and localization in C. elegans. Wojtyniak M, et al. J Cell Sci, 2013 Oct 1. PMID 23886944, Free PMC Article
    2. Defining specificity determinants of cGMP mediated gustatory sensory transduction in Caenorhabditis elegans. Smith HK, et al. Genetics, 2013 Aug. PMID 23695300, Free PMC Article
    3. Specific neuroanatomical changes in chemosensory mutants of the nematode Caenorhabditis elegans. Lewis JA, et al. J Comp Neurol, 1977 Apr 1. PMID 838889
    4. Odorant-selective genes and neurons mediate olfaction in C. elegans. Bargmann CI, et al. Cell, 1993 Aug 13. PMID 8348618
    5. Mutant sensory cilia in the nematode Caenorhabditis elegans. Perkins LA, et al. Dev Biol, 1986 Oct. PMID 2428682

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cGMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly cAMP-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly cGMP-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of intracellular cyclic nucleotide activated cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Cyclic nucleotide-binding domain-containing protein
    NP_001343628.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2104056..2111408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356910.3 → NP_001343628.1  Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61827
      Conserved Domains (3) summary
      PLN03192
      Location:303 → 581
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd00038
      Location:433 → 544
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:68 → 245
      Ion_trans; Ion transport protein
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools