acdh-12 Very long-chain specific acyl-CoA dehydrogenase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: acdh-12
Official Full Name: Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
Primary source: WormBase:WBGene00017125
Locus tag: CELE_E04F6.5
See related: AllianceGenome:WB:WBGene00017125
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable fatty-acyl-CoA binding activity and very-long-chain fatty acyl-CoA dehydrogenase activity. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in very long chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADVL (acyl-CoA dehydrogenase very long chain). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See acdh-12 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (7192434..7194770, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors demonstrate for the first time that a deficiency of ACDH-12 affects the formation and function of complex I. They suggest that in Caenorhabditis elegans, ACDH-12 is required for the assembly of the respiratory complex I, but may not be crucial to fatty acid oxidation.
Title: Identification of a novel mitochondrial complex I assembly factor ACDH-12 in Caenorhabditis elegans.
Purified very-long-chain acyl-CoA dehydrogenase (12 mg ml(-1)) was successfully crystallized by the hanging-drop vapour-diffusion method under conditions containing 100 mM Tris-HCl pH 8.0, 150 mM sodium chloride, 200 mM magnesium formate and 13% PEG 3350.
Title: Purification, crystallization and preliminary crystallographic analysis of very-long-chain acyl-CoA dehydrogenase from Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

E04F6.5 (e-PCR)
- UniSTS:309529

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables fatty-acyl-CoA binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
enables very-long-chain fatty acyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

NP_001022062.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

7192434..7194770 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026891.7 → NP_001022062.1 Very long-chain specific acyl-CoA dehydrogenase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022062.1

Status: REVIEWED

UniProtKB/TrEMBL

Q19057

Conserved Domains (2) summary

cd01161
Location:41 → 449

VLCAD; Very long chain acyl-CoA dehydrogenase

COG1960
Location:61 → 441

CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]