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    nep-17 Peptidase_M13_N domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174996, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nep-17
    Official Full Name
    Peptidase_M13_N domain-containing protein
    Primary source
    WormBase:WBGene00010070
    Locus tag
    CELE_F54F11.2
    See related
    AllianceGenome:WB:WBGene00010070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Located in membrane raft. Is expressed in intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nep-17 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    14
    Sequence:
    Chromosome: II; NC_003280.10 (13507819..13516478)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene SGNH_hydro domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serpentine receptor class epsilon-45 Neighboring gene ncRNA Neighboring gene Sorting nexin-12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assessment of Caenorhabditis elegans as a model in Haemonchus contortus vaccine research. Geldhof P, et al. Mol Biochem Parasitol, 2007 Apr. PMID 17234278
    2. The silencing of ets-4 mRNA relies on the functional cooperation between REGE-1/Regnase-1 and RLE-1/Roquin-1. Sobańska D, et al. Nucleic Acids Res, 2022 Aug 12. PMID 35819231, Free PMC Article
    3. The ELT-2 GATA-factor and the global regulation of transcription in the C. elegans intestine. McGhee JD, et al. Dev Biol, 2007 Feb 15. PMID 17113066
    4. An analysis of the Caenorhabditis elegans lipid raft proteome using geLC-MS/MS. Rao W, et al. J Proteomics, 2011 Feb 1. PMID 21070894
    5. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Peptidase_M13_N domain-containing protein
    NP_001254395.1
    • Confirmed by transcript evidence
    NP_001254396.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13507819..13516478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267466.3 → NP_001254395.1  Peptidase_M13_N domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254395.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45569
      Conserved Domains (2) summary
      cd08662
      Location:884 → 1581
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:108 → 833
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

    2. NM_001267467.3 → NP_001254396.1  Peptidase_M13_N domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254396.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6VQ96
      Conserved Domains (2) summary
      cd08662
      Location:755 → 1452
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:751 → 1454
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version

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