crb-1 uncharacterized protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: crb-1
Official Full Name: uncharacterized protein
Primary source: WormBase:WBGene00000792
Locus tag: CELE_F11C7.4
See related: AllianceGenome:WB:WBGene00000792
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in establishment or maintenance of epithelial cell apical/basal polarity and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in apical part of cell and cytoplasm. Is expressed in intestinal cell. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 9; pigmented paravenous chorioretinal atrophy; retinal disease (multiple); and ventriculomegaly - cystic kidney disease. Orthologous to several human genes including CRB1 (crumbs cell polarity complex component 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See crb-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 30

Sequence:: Chromosome: X; NC_003284.9 (17402532..17414014, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Removal of this single isoform of creb1/crh-1 shows defects in long-term memory formation in the animal and expression of CREB1/CRH-1e in a single pair of neurons is sufficient to rescue the memory defects seen in the mutant animals
Title: Differential Regulation of Innate and Learned Behavior by Creb1/Crh-1 in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F11C7.4 (e-PCR)
- UniSTS:309689

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uncharacterized protein

NP_510822.1

Product from WormBase gene class crb;
Confirmed by transcript evidence; Drosophila CRumBs homolog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

17402532..17414014 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078421.6 → NP_510822.1 uncharacterized protein CELE_F11C7.4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510822.1

Status: REVIEWED

UniProtKB/TrEMBL

Q19350

Conserved Domains (5) summary

PHA03099
Location:1613 → 1682

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

cd00054
Location:1558 → 1593

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:760 → 912

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam02210
Location:582 → 694

Laminin_G_2; Laminin G domain

cl22861
Location:1029 → 1088

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...