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    cav-2 Caveolin-2 [ Caenorhabditis elegans ]

    Gene ID: 179838, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cav-2
    Official Full Name
    Caveolin-2
    Primary source
    WormBase:WBGene00000302
    Locus tag
    CELE_C56A3.7
    See related
    AllianceGenome:WB:WBGene00000302
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables lipid transporter activity. Involved in parturition and regulation of egg-laying behavior. Located in apical plasma membrane. Is expressed in hypodermis; intestine; nervous system; pharynx; and reproductive system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cav-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    10
    Sequence:
    Chromosome: V; NC_003283.11 (13557104..13559922)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat-containing protein Neighboring gene EF-hand domain-containing protein Neighboring gene Phosphatidylinositol 4-kinase type 2 Neighboring gene Ground-like domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of caveolins in Caenorhabditis elegans induces changes in egg-laying and fecundity. Parker S, et al. Commun Integr Biol, 2009 Sep. PMID 19907693, Free PMC Article
    2. Identification, sequence, and expression of an invertebrate caveolin gene family from the nematode Caenorhabditis elegans. Implications for the molecular evolution of mammalian caveolin genes. Tang Z, et al. J Biol Chem, 1997 Jan 24. PMID 8999956
    3. Post-synaptic GABA(A) receptors potentiate transmission by recruiting CaV2 channels to their inputs. Zhao J, et al. Cell Rep, 2023 Oct 31. PMID 37742192, Free PMC Article
    4. Caveolin-2 is required for apical lipid trafficking and suppresses basolateral recycling defects in the intestine of Caenorhabditis elegans. Parker S, et al. Mol Biol Cell, 2009 Mar. PMID 19158391, Free PMC Article
    5. CHE-14, a protein with a sterol-sensing domain, is required for apical sorting in C. elegans ectodermal epithelial cells. Michaux G, et al. Curr Biol, 2000 Sep 21. PMID 10996790

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Post-synaptic GABAA receptors potentiate transmission by recruiting CaV2 channels to their inputs.
      Title: Post-synaptic GABA(A) receptors potentiate transmission by recruiting CaV2 channels to their inputs.
    2. CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles.
      Title: CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles.
    3. caveolin-2 is an integral component of the trafficking network in the intestinal cells of C. elegans
      Title: Caveolin-2 is required for apical lipid trafficking and suppresses basolateral recycling defects in the intestine of Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lipid transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in caveola assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in caveola assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in parturition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of egg-laying behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with caveola IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in caveola IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in caveola TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Caveolin-2
    NP_001256523.1
    • Confirmed by transcript evidence
    NP_001256524.1
    • Confirmed by transcript evidence
    NP_001256525.1
    • Confirmed by transcript evidence
    NP_001256526.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13557104..13559922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269594.3 → NP_001256523.1  Caveolin-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256523.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1B6T3, E1B6T4, G3MU34, Q18879
      Conserved Domains (1) summary
      pfam01146
      Location:209 → 335
      Caveolin; Caveolin

    2. NM_001269595.3 → NP_001256524.1  Caveolin-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256524.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18879
      Conserved Domains (1) summary
      pfam01146
      Location:139 → 265
      Caveolin; Caveolin

    3. NM_001269596.3 → NP_001256525.1  Caveolin-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256525.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18879
      Conserved Domains (1) summary
      pfam01146
      Location:177 → 303
      Caveolin; Caveolin

    4. NM_001269597.3 → NP_001256526.1  Caveolin-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256526.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18879
      Conserved Domains (1) summary
      pfam01146
      Location:18 → 144
      Caveolin; Caveolin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18879.3

    Gene LinkOut

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