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    tre-2 Trehalase [ Caenorhabditis elegans ]

    Gene ID: 177451, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tre-2
    Official Full Name
    Trehalase
    Primary source
    WormBase:WBGene00006608
    Locus tag
    CELE_T05A12.2
    See related
    AllianceGenome:WB:WBGene00006608
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable alpha,alpha-trehalase activity. Predicted to be involved in trehalose catabolic process. Is expressed in several structures, including enteric muscle; excretory gland cell; head mesodermal cell; nervous system; and reproductive system. Orthologous to human TREH (trehalase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tre-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (6876731..6883442, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene 7TM GPCR serpentine receptor class x (Srx) domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein SPT2 homolog Neighboring gene RING-type domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of O-GlcNAc Cycling in C. elegans Perturbs Nucleotide Sugar Pools and Complex Glycans. Ghosh SK, et al. Front Endocrinol (Lausanne), 2014. PMID 25505447, Free PMC Article
    2. Intrapopulation analysis of longitudinal lifespan in Caenorhabditis elegans identifies W09D10.4 as a novel AMPK-associated healthspan shortening factor. Nakano Y, et al. J Pharmacol Sci, 2021 Mar. PMID 33602504
    3. Trehalose metabolism genes in Caenorhabditis elegans and filarial nematodes. Pellerone FI, et al. Int J Parasitol, 2003 Sep 30. PMID 13678635
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables alpha,alpha-trehalase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha,alpha-trehalase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in trehalose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in trehalose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Trehalase
    NP_001293773.1
    • Confirmed by transcript evidence
    NP_001368400.1
    • Confirmed by transcript evidence
    NP_501058.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6876731..6883442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068657.7 → NP_501058.2  Trehalase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501058.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GYK9
      Conserved Domains (1) summary
      pfam01204
      Location:107 → 607
      Trehalase; Trehalase

    2. NM_001306844.3 → NP_001293773.1  Trehalase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293773.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K866
      Conserved Domains (1) summary
      pfam01204
      Location:21 → 521
      Trehalase; Trehalase

    3. NM_001380293.1 → NP_001368400.1  Trehalase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CKD9
      Conserved Domains (1) summary
      pfam01204
      Location:6 → 475
      Trehalase
    Nucleotide Protein
    Heading Accession and Version

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