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    pdcd-2 MYND-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 259501, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pdcd-2
    Official Full Name
    MYND-type domain-containing protein
    Primary source
    WormBase:WBGene00011116
    Locus tag
    CELE_R07E5.10
    See related
    AllianceGenome:WB:WBGene00011116
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in vacuolar proton-transporting V-type ATPase complex assembly. Predicted to be located in cytoplasm. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in X-linked myopathy with excessive autophagy. Orthologous to human VMA21 (vacuolar ATPase assembly factor VMA21). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pdcd-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (4415521..4417812, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative mitochondrial pyruvate carrier 1 Neighboring gene ncRNA Neighboring gene Intraflagellar transport protein 46 homolog Neighboring gene Vacuolar ATPase assembly integral membrane protein VMA21 homolog Neighboring gene Uncharacterized protein Neighboring gene ATP-dependent DNA helicase II subunit 2;Ku C-terminal domain-containing protein;Ku_PK_bind domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Synteny of orthologous genes conserved in mammals, snake, fly, nematode, and fission yeast. Trachtulec Z, et al. Mamm Genome, 2001 Mar. PMID 11252172
    2. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    3. Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. Lehner B, et al. Nat Genet, 2006 Aug. PMID 16845399
    4. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in vacuolar proton-transporting V-type ATPase complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MYND-type domain-containing protein
    NP_497896.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4415521..4417812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065495.10 → NP_497896.1  MYND-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497896.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21826
      Conserved Domains (2) summary
      pfam01753
      Location:146 → 182
      zf-MYND; MYND finger
      pfam04194
      Location:269 → 384
      PDCD2_C; Programmed cell death protein 2, C-terminal putative domain
    Nucleotide Protein
    Heading Accession and Version

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