ceh-30 Homeobox protein ceh-30 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ceh-30
Official Full Name: Homeobox protein ceh-30
Primary source: WormBase:WBGene00000451
Locus tag: CELE_C33D12.7
See related: AllianceGenome:WB:WBGene00000451
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of apoptotic process; nervous system development; and sex differentiation. Located in nucleus. Is expressed in embryonic cell and neurons. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma. Orthologous to human BARHL2 (BarH like homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ceh-30 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 3

Sequence:: Chromosome: X; NC_003284.9 (3063574..3065551)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ceh-30 defines a checkpoint that integrates the sex determination signal TRA-1 and the cell fate determination and survival signal UNC-86 to control the sex-specific activation of the apoptosis program in sensory neurons through UNC-37.
Title: Control of sex-specific apoptosis in C. elegans by the BarH homeodomain protein CEH-30 and the transcriptional repressor UNC-37/Groucho.
ceh-30 acts within the male-specific CEM (cephalic male) sensory neurons to promote their survival independently of both egl-1 and ced-9.
Title: The C. elegans protein CEH-30 protects male-specific neurons from apoptosis independently of the Bcl-2 homolog CED-9.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C33D12.7 (e-PCR)
- UniSTS:319102

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sex differentiation	IEA Inferred from Electronic Annotation more info
involved_in sex differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Homeobox protein ceh-30

NP_508524.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

3063574..3065551

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076123.6 → NP_508524.2 Homeobox protein ceh-30 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508524.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22909

Conserved Domains (1) summary

pfam00046
Location:99 → 151

Homeobox; Homeobox domain