T09B4.8 Alanine--glyoxylate aminotransferase 2, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: T09B4.8
Official Full Name: Alanine--glyoxylate aminotransferase 2, mitochondrial
Primary source: WormBase:WBGene00020382
Locus tag: CELE_T09B4.8
See related: AllianceGenome:WB:WBGene00020382
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable alanine-glyoxylate transaminase activity. Predicted to be involved in L-alanine catabolic process, by transamination and glyoxylate catabolic process. Predicted to be active in mitochondrion. Is expressed in body wall musculature; hypodermis; intestine; and nervous system. Human ortholog(s) of this gene implicated in artery disease (multiple); atrial fibrillation; cerebral infarction; congestive heart failure; and mild cognitive impairment. Orthologous to human AGXT2 (alanine--glyoxylate aminotransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See T09B4.8 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (6164719..6166539, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS1-145 (e-PCR)
- UniSTS:241631

T09B4.8 (e-PCR)
- UniSTS:310755

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables alanine-glyoxylate transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-alanine catabolic process, by transamination	IBA Inferred from Biological aspect of Ancestor more info
involved_in glyoxylate catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Alanine--glyoxylate aminotransferase 2, mitochondrial

NP_491777.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6164719..6166539 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059376.11 → NP_491777.3 Alanine--glyoxylate aminotransferase 2, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491777.3

Status: REVIEWED

UniProtKB/TrEMBL

O02158

Conserved Domains (2) summary

cd00610
Location:14 → 440

OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...

COG0160
Location:1 → 442

GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]