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    pin-2 LIM domain-containing protein pin-2 [ Caenorhabditis elegans ]

    Gene ID: 178234, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pin-2
    Official Full Name
    LIM domain-containing protein pin-2
    Primary source
    WormBase:WBGene00004030
    Locus tag
    CELE_F07C6.1
    See related
    AllianceGenome:WB:WBGene00004030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in several processes, including cell-cell junction organization; positive regulation of integrin-mediated signaling pathway; and positive regulation of substrate adhesion-dependent cell spreading. Located in cytoplasm; nucleus; and varicosity. Is expressed in PVT. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pin-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (12793847..12796164)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene CcmD family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Cytohesin Ubiquitin Protein Inducing domain-containing protein;FERM domain-containing protein Neighboring gene Bax inhibitor-1 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. Hobert O, et al. J Cell Biol, 1999 Jan 11. PMID 9885243, Free PMC Article
    2. Differential functions of the C. elegans FGF receptor in axon outgrowth and maintenance of axon position. Bülow HE, et al. Neuron, 2004 May 13. PMID 15134634
    3. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in varicosity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LIM domain-containing protein pin-2
    NP_001255672.1
    • Confirmed by transcript evidence
    NP_001255673.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12793847..12796164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268743.3 → NP_001255672.1  LIM domain-containing protein pin-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255672.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H9G2V0, H9G2V1, Q19157
      Conserved Domains (3) summary
      cd09331
      Location:21 → 79
      LIM1_PINCH; The first LIM domain of protein PINCH
      cd09334
      Location:200 → 256
      LIM4_PINCH; The fourth LIM domain of protein PINCH
      cl02475
      Location:264 → 315
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. NM_001268744.3 → NP_001255673.1  LIM domain-containing protein pin-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255673.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19157
      Conserved Domains (1) summary
      cl02475
      Location:1 → 41
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19157.2

    Gene LinkOut

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