cyb-3 G2/mitotic-specific cyclin-B3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cyb-3
Official Full Name: G2/mitotic-specific cyclin-B3
Primary source: WormBase:WBGene00000868
Locus tag: CELE_T06E6.2
See related: AllianceGenome:WB:WBGene00000868
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including chromosome organization; positive regulation of mitotic metaphase/anaphase transition; and pronuclear migration. Acts upstream of or within nematode male tail tip morphogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including AB; EMS; Psub1; germ line; and gonad. Orthologous to human CCNB3 (cyclin B3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cyb-3 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (15395696..15397351)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cyclin B3 is a dominant fast-acting cyclin that drives rapid early embryonic mitoses.
Title: Cyclin B3 is a dominant fast-acting cyclin that drives rapid early embryonic mitoses.
The findings highlight the importance of the CYB-3 B3-type cyclin in cell cycle regulation in the early embryo and suggest that CYB-3 asymmetry helps establish the well-documented cell cycle asynchrony that occurs during cell division within the P-lineage.
Title: Cyclin CYB-3 controls both S-phase and mitosis and is asymmetrically distributed in the early C. elegans embryo.
Mutations affecting dhc-1 and cyb-3 cooperate to increase fitness in the absence of MDF-1.
Title: Cyclin B3 and dynein heavy chain cooperate to increase fitness in the absence of mdf-1/MAD1 in Caenorhabditis elegans.
CYB-3 plays a unique, essential role in the cell cycle including promoting mitotic dynein functionality.
Title: Caenorhabditis elegans cyclin B3 is required for multiple mitotic processes including alleviation of a spindle checkpoint-dependent block in anaphase chromosome segregation.
Data show that doubling the CYB-3 (Cyclin B3) dosage suppresses sterility in the absence of the essential spindle assembly checkpoint component MDF-1 without causing a delay in the onset of anaphase.
Title: Duplication of cyb-3 (cyclin B3) suppresses sterility in the absence of mdf-1/MAD1 spindle assembly checkpoint component in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T06E6.1 (e-PCR)
- UniSTS:307953

T06E6.2 (e-PCR)
- UniSTS:307954

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kinetochore organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle phase transition	IEA Inferred from Electronic Annotation more info
involved_in mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte maturation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of mitotic metaphase/anaphase transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in pronuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G2/mitotic-specific cyclin-B3

NP_001024112.2

Confirmed by transcript evidence

NP_506825.4

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

15395696..15397351

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028941.4 → NP_001024112.2 G2/mitotic-specific cyclin-B3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024112.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q10654

Conserved Domains (2) summary

pfam00134
Location:115 → 240

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:242 → 363

Cyclin_C; Cyclin, C-terminal domain
NM_074424.10 → NP_506825.4 G2/mitotic-specific cyclin-B3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506825.4

Status: REVIEWED

UniProtKB/Swiss-Prot

Q10654, Q95ZP8, Q9U378

Conserved Domains (2) summary

pfam00134
Location:116 → 241

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:243 → 364

Cyclin_C; Cyclin, C-terminal domain