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    T05A12.4 RING-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177453, updated on 9-Dec-2024

    Summary

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    Official Symbol
    T05A12.4
    Official Full Name
    RING-type domain-containing protein
    Primary source
    WormBase:WBGene00020235
    Locus tag
    CELE_T05A12.4
    See related
    AllianceGenome:WB:WBGene00020235
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in DNA damage response and protein polyubiquitination. Orthologous to human SHPRH (SNF2 histone linker PHD RING helicase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See T05A12.4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    23
    Sequence:
    Chromosome: IV; NC_003282.8 (6887948..6897783)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Trehalase Neighboring gene ncRNA Neighboring gene Protein SPT2 homolog Neighboring gene ncRNA Neighboring gene SRCR domain-containing protein Neighboring gene EF-hand domain-containing protein Neighboring gene Col_cuticle_N domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RING-type domain-containing protein
    NP_001023359.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6887948..6897783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028188.5 → NP_001023359.1  RING-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023359.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0J8
      Conserved Domains (4) summary
      COG0553
      Location:1429 → 1563
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      pfam00176
      Location:297 → 670
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1425 → 1537
      Helicase_C; Helicase conserved C-terminal domain
      pfam13923
      Location:1346 → 1392
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
    Nucleotide Protein
    Heading Accession and Version

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