U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cut-6 Cuticlin-6 [ Caenorhabditis elegans ]

    Gene ID: 176520, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cut-6
    Official Full Name
    Cuticlin-6
    Primary source
    WormBase:WBGene00000853
    Locus tag
    CELE_M142.2
    See related
    AllianceGenome:WB:WBGene00000853
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of cuticle. Located in alae of collagen and cuticulin-based cuticle extracellular matrix. Is expressed in hypodermal cell. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cut-6 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (10911460..10916665)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DNA endonuclease activator Ctp1 C-terminal domain-containing protein Neighboring gene GMP phosphodiesterase delta subunit domain-containing protein;Protein unc-119 Neighboring gene Homeobox protein vab-7 Neighboring gene pseudo

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Zona Pellucida domain containing proteins, CUT-1, CUT-3 and CUT-5, play essential roles in the development of the larval alae in Caenorhabditis elegans. Sapio MR, et al. Dev Biol, 2005 Jun 1. PMID 15936343
    2. M142.2 (cut-6), a novel Caenorhabditis elegans matrix gene important for dauer body shape. Muriel JM, et al. Dev Biol, 2003 Aug 15. PMID 12921736
    3. Identification and characterization of epicuticular proteins of nematodes sharing motifs with cuticular proteins of arthropods. Betschart B, et al. PLoS One, 2022. PMID 36301857, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. characterization of the gene M142.2; findings show that this is a developmentally regulated gene important for cuticle structure
      Title: M142.2 (cut-6), a novel Caenorhabditis elegans matrix gene important for dauer body shape.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in alae of collagen and cuticulin-based cuticle extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Cuticlin-6
    NP_499400.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10911460..10916665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066999.8 → NP_499400.2  Cuticlin-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499400.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21540
      Conserved Domains (2) summary
      smart00241
      Location:233 → 480
      ZP; Zona pellucida (ZP) domain
      pfam00092
      Location:48 → 208
      VWA; von Willebrand factor type A domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21540.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools