U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    syp-2 Biogenesis of lysosome-related organelles complex 1 subunit 1 [ Caenorhabditis elegans ]

    Gene ID: 178938, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    syp-2
    Official Full Name
    Biogenesis of lysosome-related organelles complex 1 subunit 1
    Primary source
    WormBase:WBGene00006376
    Locus tag
    CELE_C24G6.1
    See related
    AllianceGenome:WB:WBGene00006376
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in positive regulation of reciprocal meiotic recombination and synaptonemal complex assembly. Located in central element. Is expressed in germ cell; germ line; gonad; and midbody. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See syp-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (5536487..5537717)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene receptor protein-tyrosine kinase Neighboring gene Ground-like domain-containing protein Neighboring gene putative peptidyl-tRNA hydrolase 2 Neighboring gene Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial Neighboring gene Cystic Fibrosis Transmembrane conductance regulator homolog Neighboring gene Putative UDP-glucuronosyltransferase ugt-48 Neighboring gene pseudo

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A motor independent requirement for dynein light chain in Caenorhabditis elegans meiotic synapsis. Fielder SM, et al. Genetics, 2022 Jan 4. PMID 34788833, Free PMC Article
    2. HTP-1-dependent constraints coordinate homolog pairing and synapsis and promote chiasma formation during C. elegans meiosis. Martinez-Perez E, et al. Genes Dev, 2005 Nov 15. PMID 16291646, Free PMC Article
    3. Crossing over is coupled to late meiotic prophase bivalent differentiation through asymmetric disassembly of the SC. Nabeshima K, et al. J Cell Biol, 2005 Feb 28. PMID 15738262, Free PMC Article
    4. The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis. Nadarajan S, et al. Elife, 2016 Feb 27. PMID 26920220, Free PMC Article
    5. Sexual dimorphic regulation of recombination by the synaptonemal complex in C. elegans. Cahoon CK, et al. Elife, 2023 Oct 5. PMID 37796106, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in central element IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Biogenesis of lysosome-related organelles complex 1 subunit 1
    NP_504462.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5536487..5537717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072061.7 → NP_504462.1  Biogenesis of lysosome-related organelles complex 1 subunit 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504462.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76388
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools