tat-2 Phospholipid-transporting ATPase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tat-2
Official Full Name: Phospholipid-transporting ATPase
Primary source: WormBase:WBGene00019166
Locus tag: CELE_H06H21.10
See related: AllianceGenome:WB:WBGene00019166
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Involved in sterol metabolic process. Predicted to be located in membrane. Predicted to be active in plasma membrane and trans-Golgi network. Is expressed in several structures, including excretory system; gonad; pharynx; rectal gland cell; and vulva. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 1; intrahepatic cholestasis; intrahepatic cholestasis of pregnancy 1; and progressive familial intrahepatic cholestasis 1. Orthologous to several human genes including ATP8B4 (ATPase phospholipid transporting 8B4 (putative)). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tat-2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 24

Sequence:: Chromosome: IV; NC_003282.8 (4827853..4846893, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TAT-2 has a specific role in antagonizing the regulatory activity of monomethyl branched-chain fatty acid in intestinal cells.
Title: P-type ATPase TAT-2 negatively regulates monomethyl branched-chain fatty acid mediated function in post-embryonic growth and development in C. elegans.

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General gene information

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Markers

H06H21.10 (e-PCR)
- UniSTS:314561

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled intramembrane lipid transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled intramembrane lipid transporter activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid transport	IEA Inferred from Electronic Annotation more info
involved_in sterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Phospholipid-transporting ATPase

NP_001023252.2

Confirmed by transcript evidence

NP_001294444.1

Confirmed by transcript evidence

NP_001294445.1

Partially confirmed by transcript evidence

NP_001294446.1

Confirmed by transcript evidence

NP_001294447.1

Confirmed by transcript evidence

NP_001367920.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

4827853..4846893 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001307517.3 → NP_001294446.1 Phospholipid-transporting ATPase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294446.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PBI0

Conserved Domains (6) summary

TIGR01652
Location:71 → 1178

ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

pfam13246
Location:526 → 615

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:60 → 122

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:916 → 1172

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

cl00297
Location:675 → 738

R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...

cl21460
Location:885 → 916

HAD_like; Haloacid Dehalogenase-like Hydrolases
NM_001307518.3 → NP_001294447.1 Phospholipid-transporting ATPase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294447.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PBV8

Conserved Domains (6) summary

TIGR01652
Location:71 → 1178

ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

pfam13246
Location:526 → 615

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:60 → 122

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:916 → 1172

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

cl00297
Location:675 → 738

R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...

cl21460
Location:885 → 916

HAD_like; Haloacid Dehalogenase-like Hydrolases
NM_001380211.1 → NP_001367920.1 Phospholipid-transporting ATPase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q7YXV5

Conserved Domains (1) summary

cd02073
Location:38 → 1013

P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
NM_001028081.3 → NP_001023252.2 Phospholipid-transporting ATPase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023252.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9TXV2

Conserved Domains (6) summary

TIGR01652
Location:36 → 1143

ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

pfam13246
Location:491 → 580

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:25 → 87

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:881 → 1137

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

cl00297
Location:640 → 703

R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...

cl21460
Location:850 → 881

HAD_like; Haloacid Dehalogenase-like Hydrolases
NM_001307516.1 → NP_001294445.1 Phospholipid-transporting ATPase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294445.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PEQ6

Conserved Domains (6) summary

TIGR01652
Location:71 → 1178

ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

pfam13246
Location:526 → 615

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:60 → 122

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:916 → 1172

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

cl00297
Location:675 → 738

R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...

cl21460
Location:885 → 916

HAD_like; Haloacid Dehalogenase-like Hydrolases
NM_001307515.3 → NP_001294444.1 Phospholipid-transporting ATPase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294444.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PRL1

Conserved Domains (6) summary

TIGR01652
Location:36 → 1143

ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

pfam13246
Location:491 → 580

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:25 → 87

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:881 → 1137

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

cl00297
Location:640 → 703

R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...

cl21460
Location:850 → 881

HAD_like; Haloacid Dehalogenase-like Hydrolases