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    osm-8 Osmotic avoidance abnormal protein 8 [ Caenorhabditis elegans ]

    Gene ID: 187684, updated on 9-Dec-2024

    Summary

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    Official Symbol
    osm-8
    Official Full Name
    Osmotic avoidance abnormal protein 8
    Primary source
    WormBase:WBGene00003888
    Locus tag
    CELE_R07G3.6
    See related
    AllianceGenome:WB:WBGene00003888
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in regulation of gene expression and response to osmotic stress. Located in extracellular space. Is expressed in hyp7 syncytium. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See osm-8 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003280.10 (7604196..7605406, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Serine/threonine-protein phosphatase Pgam5, mitochondrial Neighboring gene TPR_MLP1_2 domain-containing protein Neighboring gene LIPaSe related Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extracellular proteins OSM-7 and OSM-8 are required for stress response gene regulation at all post-embryonic stages. Rodriguez Mendoza V, et al. MicroPubl Biol, 2022. PMID 36606078, Free PMC Article
    2. The Caenorhabditis elegans mucin-like protein OSM-8 negatively regulates osmosensitive physiology via the transmembrane protein PTR-23. Rohlfing AK, et al. PLoS Genet, 2011 Jan 6. PMID 21253570, Free PMC Article
    3. Caenorhabditis elegans bacterial pathogen resistant bus-4 mutants produce altered mucins. Parsons LM, et al. PLoS One, 2014. PMID 25296196, Free PMC Article
    4. An extracellular matrix damage sensor signals through membrane-associated kinase DRL-1 to mediate cytoprotective responses in Caenorhabditis elegans. Wimberly K, et al. Genetics, 2022 Mar 3. PMID 34849856, Free PMC Article
    5. Genetic and physiological activation of osmosensitive gene expression mimics transcriptional signatures of pathogen infection in C. elegans. Rohlfing AK, et al. PLoS One, 2010 Feb 2. PMID 20126308, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Osmotic avoidance abnormal protein 8
    NP_495595.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7604196..7605406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063194.8 → NP_495595.2  Osmotic avoidance abnormal protein 8 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09423
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09423.2

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