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    • Showing Current items.

    clp-4 Calpain clp-4 [ Caenorhabditis elegans ]

    Gene ID: 175326, updated on 9-Dec-2024

    Summary

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    Official Symbol
    clp-4
    Official Full Name
    Calpain clp-4
    Primary source
    WormBase:WBGene00000545
    Locus tag
    CELE_Y39A3CL.5
    See related
    AllianceGenome:WB:WBGene00000545
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Is expressed in body wall musculature; excretory cell; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; hereditary spastic paraplegia 76; muscular dystrophy; and stomach cancer. Orthologous to several human genes including CAPN1 (calpain 1); CAPN11 (calpain 11); and CAPN2 (calpain 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See clp-4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (1807740..1818323, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Variant SH3 domain protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Platelet-derived growth factor (PDGF) family profile domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative Analysis of Muscle Atrophy During Spaceflight, Nutritional Deficiency and Disuse in the Nematode Caenorhabditis elegans. Kim BS, et al. Int J Mol Sci, 2023 Aug 10. PMID 37628820, Free PMC Article
    2. Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans. Syntichaki P, et al. Nature, 2002 Oct 31. PMID 12410314
    3. Regulation of tissue-specific and extracellular matrix-related genes by a class I histone deacetylase. Whetstine JR, et al. Mol Cell, 2005 May 13. PMID 15893731
    4. Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. Crawford ED, et al. Cell Death Differ, 2012 Dec. PMID 22918439, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium-dependent cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Calpain clp-4
    NP_497460.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      1807740..1818323 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065059.10 → NP_497460.2  Calpain clp-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497460.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IAA9
      UniProtKB/TrEMBL
      Q8IAA8
      Conserved Domains (2) summary
      cd00214
      Location:560 → 716
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      pfam00648
      Location:241 → 534
      Peptidase_C2; Calpain family cysteine protease
    Nucleotide Protein
    Heading Accession and Version

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