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    hxk-3 Phosphotransferase [ Caenorhabditis elegans ]

    Gene ID: 176958, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hxk-3
    Official Full Name
    Phosphotransferase
    Primary source
    WormBase:WBGene00022306
    Locus tag
    CELE_Y77E11A.1
    See related
    AllianceGenome:WB:WBGene00022306
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fructokinase activity and glucokinase activity. Predicted to be involved in several processes, including glucose 6-phosphate metabolic process; glycolytic process; and intracellular glucose homeostasis. Predicted to be active in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hxk-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (1499862..1509962)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class D (Delta) Neighboring gene ncRNA Neighboring gene Protein SEC13 homolog Neighboring gene ncRNA Neighboring gene Fungal lipase-like domain-containing protein Neighboring gene tRNA-Asp Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Toxicity and metabolism of 3-bromopyruvate in Caenorhabditis elegans. Gu QL, et al. J Zhejiang Univ Sci B, 2020 Jan.. PMID 31898444, Free PMC Article
    2. The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Mouchiroud L, et al. Cell, 2013 Jul 18. PMID 23870130, Free PMC Article
    3. Glyceraldehyde-3-phosphate dehydrogenase mediates anoxia response and survival in Caenorhabditis elegans. Mendenhall AR, et al. Genetics, 2006 Nov. PMID 16980394, Free PMC Article
    4. Dietary restriction by growth in axenic medium induces discrete changes in the transcriptional output of genes involved in energy metabolism in Caenorhabditis elegans. Castelein N, et al. Biotechnol J, 2008 Jun. PMID 18383023
    5. Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans. McElwee JJ, et al. Mech Ageing Dev, 2006 May. PMID 16522328

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-glucose binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hexose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular glucose homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Phosphotransferase
    NP_001294488.1
    • Confirmed by transcript evidence
    NP_001294489.1
    • Confirmed by transcript evidence
    NP_001370784.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1499862..1509962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383041.2 → NP_001370784.1  Phosphotransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N4A5
      Conserved Domains (2) summary
      COG5026
      Location:7 → 448
      COG5026; Hexokinase [Carbohydrate transport and metabolism]
      pfam00349
      Location:7 → 202
      Hexokinase_1

    2. NM_001307559.3 → NP_001294488.1  Phosphotransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294488.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBN7
      Conserved Domains (1) summary
      pfam03727
      Location:21 → 256
      Hexokinase_2; Hexokinase

    3. NM_001307560.3 → NP_001294489.1  Phosphotransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294489.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PC09
      Conserved Domains (1) summary
      pfam03727
      Location:1 → 202
      Hexokinase_2; Hexokinase
    Nucleotide Protein
    Heading Accession and Version

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