glf-1 Amine oxidase domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: glf-1
Official Full Name: Amine oxidase domain-containing protein
Primary source: WormBase:WBGene00019154
Locus tag: CELE_H04M03.4
See related: AllianceGenome:WB:WBGene00019154
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables UDP-galactopyranose mutase activity. Involved in polysaccharide biosynthetic process. Located in cytoplasm. Is expressed in hypodermis; muscle cell; and neurons. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See glf-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (5885835..5889821)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Biosynthetic incorporation of Galf into glycoconjugates depends upon generation of the glycosyl donor UDP-galactofuranose (Galf) by the flavoenzyme uridine 5'-diphosphate (UDP) galactopyranose mutase (UGM or Glf).
Title: UDP-galactopyranose mutase in nematodes.
UDP-Gal(f) was detected in wild-type animals while absent in glf-1 deletion mutants
Title: Characterization of the Caenorhabditis elegans UDP-galactopyranose mutase homolog glf-1 reveals an essential role for galactofuranose metabolism in nematode surface coat synthesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H04M03.4 (e-PCR)
- UniSTS:317381

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables UDP-galactopyranose mutase activity	IEA Inferred from Electronic Annotation more info
enables UDP-galactopyranose mutase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in polysaccharide biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Amine oxidase domain-containing protein

NP_500884.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

5885835..5889821

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068483.5 → NP_500884.2 Amine oxidase domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500884.2

Status: REVIEWED

UniProtKB/TrEMBL

G5ECS4

Conserved Domains (1) summary

COG1232
Location:1 → 457

HemY; Protoporphyrinogen oxidase [Coenzyme transport and metabolism]