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    cgr-1 CRAL-TRIO domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180650, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cgr-1
    Official Full Name
    CRAL-TRIO domain-containing protein
    Primary source
    WormBase:WBGene00020847
    Locus tag
    CELE_T27A10.7
    See related
    AllianceGenome:WB:WBGene00020847
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Located in cytoplasm. Is expressed in intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cgr-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (3597276..3600457, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene GRAM domain-containing protein Neighboring gene G domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The CRAL/TRIO and GOLD domain protein TAP-1 regulates RAF-1 activation. Johnson KG, et al. Dev Biol, 2010 May 15. PMID 20230813, Free PMC Article
    2. Quantifying Food Intake in Caenorhabditis elegans by Measuring Bacterial Clearance. Clark C, et al. J Vis Exp, 2024 Feb 23. PMID 38465935
    3. The CRAL/TRIO and GOLD domain protein CGR-1 promotes induction of vulval cell fates in Caenorhabditis elegans and interacts genetically with the Ras signaling pathway. Goldstein JL, et al. Genetics, 2006 Feb. PMID 16219793, Free PMC Article
    4. The C. elegans Snail homolog CES-1 can activate gene expression in vivo and share targets with bHLH transcription factors. Reece-Hoyes JS, et al. Nucleic Acids Res, 2009 Jun. PMID 19372275, Free PMC Article
    5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cgr-1 encodes a protein with CRAL/TRIO and GOLD domains; it positively regulates induction of vulval cell fates, is necessary for larval viability, and is a potential new regulator of Ras-mediated signaling.
      Title: The CRAL/TRIO and GOLD domain protein CGR-1 promotes induction of vulval cell fates in Caenorhabditis elegans and interacts genetically with the Ras signaling pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CRAL-TRIO domain-containing protein
    NP_508618.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      3597276..3600457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076217.7 → NP_508618.2  CRAL-TRIO domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508618.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22824
      Conserved Domains (1) summary
      smart00516
      Location:91 → 257
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    Nucleotide Protein
    Heading Accession and Version

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