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    snpn-1 SNAPIN protein homolog [ Caenorhabditis elegans ]

    Gene ID: 177282, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snpn-1
    Official Full Name
    SNAPIN protein homolog
    Primary source
    WormBase:WBGene00015327
    Locus tag
    CELE_C02B10.2
    See related
    AllianceGenome:WB:WBGene00015327
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable SNARE binding activity. Involved in endosomal transport and positive regulation of intracellular protein transport. Predicted to be part of BLOC-1 complex. Predicted to be active in secretory granule and synaptic vesicle. Used to study Hermansky-Pudlak syndrome. Orthologous to human SNAPIN (SNAP associated protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See snpn-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (5090243..5091043, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene BZIP domain-containing protein;SH3 domain-containing protein Neighboring gene Isovaleryl-CoA dehydrogenase, mitochondrial Neighboring gene RRM domain-containing protein Neighboring gene EGF-like domain-containing protein C02B10.3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential roles for snapin and synaptotagmin in the synaptic vesicle cycle. Yu SC, et al. PLoS One, 2013. PMID 23469084, Free PMC Article
    2. BORC Regulates the Axonal Transport of Synaptic Vesicle Precursors by Activating ARL-8. Niwa S, et al. Curr Biol, 2017 Sep 11. PMID 28823680, Free PMC Article
    3. C. elegans BLOC-1 functions in trafficking to lysosome-related gut granules. Hermann GJ, et al. PLoS One, 2012. PMID 22916203, Free PMC Article
    4. The relationship between intraflagellar transport and upstream protein trafficking pathways and macrocyclic lactone resistance in Caenorhabditis elegans. Brinzer RA, et al. G3 (Bethesda), 2024 Mar 6. PMID 38227795, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endosomal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of BLOC-1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BLOC-1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of BLOC-1 complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SNAPIN protein homolog
    NP_500721.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      5090243..5091043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068320.5 → NP_500721.1  SNAPIN protein homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500721.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44445
      Conserved Domains (1) summary
      pfam14712
      Location:17 → 97
      Snapin_Pallidin; Snapin/Pallidin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44445.2

    Gene LinkOut

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