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    spg-20 Inheritance of peroxisomes protein 1 [ Caenorhabditis elegans ]

    Gene ID: 172369, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spg-20
    Official Full Name
    Inheritance of peroxisomes protein 1
    Primary source
    WormBase:WBGene00019006
    Locus tag
    CELE_F57B10.9
    See related
    AllianceGenome:WB:WBGene00019006
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in cell division and negative regulation of BMP signaling pathway. Predicted to be located in peroxisomal membrane. Predicted to be extrinsic component of intraperoxisomal membrane. Predicted to be active in plasma membrane. Is expressed in body wall musculature and nervous system. Human ortholog(s) of this gene implicated in Troyer syndrome. Orthologous to human SPART (spartin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See spg-20 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (6550536..6552625, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Neighboring gene Activator of basal transcription 1 Neighboring gene Cytochrome b-c1 complex subunit 10 Neighboring gene Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oxidative Stress in Caenorhabditis elegans: Protective Effects of Spartin. Truong T, et al. PLoS One, 2015. PMID 26114733, Free PMC Article
    2. An Expanded Role for the RFX Transcription Factor DAF-19, with Dual Functions in Ciliated and Nonciliated Neurons. De Stasio EA, et al. Genetics, 2018 Mar. PMID 29301909, Free PMC Article
    3. The C. elegans regulatory factor X (RFX) DAF-19M module: A shift from general ciliogenesis to cell-specific ciliary and behavioral specialization. Ahn S, et al. Cell Rep, 2022 Apr 12. PMID 35417689
    4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peroxisome inheritance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extrinsic component of intraperoxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Inheritance of peroxisomes protein 1
    NP_491888.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6550536..6552625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059487.7 → NP_491888.2  Inheritance of peroxisomes protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491888.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44735
      Conserved Domains (3) summary
      cd02679
      Location:14 → 90
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam06911
      Location:262 → 436
      Senescence; Senescence-associated protein
      pfam12634
      Location:117 → 237
      Inp1; Inheritance of peroxisomes protein 1
    Nucleotide Protein
    Heading Accession and Version

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