pmt-2 Phosphoethanolamine N-methyltransferase 2 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: pmt-2
Official Full Name: Phosphoethanolamine N-methyltransferase 2
Primary source: WormBase:WBGene00018811
Locus tag: CELE_F54D11.1
See related: AllianceGenome:WB:WBGene00018811
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables phosphatidyl-N-methylethanolamine N-methyltransferase activity. Involved in phosphatidylcholine biosynthetic process. Orthologous to human TMT1A (thiol methyltransferase 1A) and TMT1B (thiol methyltransferase 1B). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Cloning and biochemical characterization of pmt-2 from C. elegans; PMT-2 is essential for worm viability.
Title: Defining the role of phosphomethylethanolamine N-methyltransferase from Caenorhabditis elegans in phosphocholine biosynthesis by biochemical and kinetic analysis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables S-adenosylmethionine-dependent methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidyl-N-methylethanolamine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoethanolamine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylcholine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info

NP_504248.1

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