ostd-1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ostd-1
Official Full Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
Primary source: WormBase:WBGene00019693
Locus tag: CELE_M01A10.3
See related: AllianceGenome:WB:WBGene00019693
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in endoplasmic reticulum organization and regulation of cell division. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of oligosaccharyltransferase complex. Is expressed in several structures, including body wall musculature; intestine; nervous system; pharynx; and vulval muscle. Orthologous to human RPN2 (ribophorin II). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ostd-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (5549149..5550295, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OSTD-1 plays a role in maintaining the dynamic morphology of the ER during the cell cycle
Title: Profiling of the mammalian mitotic spindle proteome reveals an ER protein, OSTD-1, as being necessary for cell division and ER morphology.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M01A10.3 (e-PCR)
- UniSTS:311943

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein N-linked glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of oligosaccharyltransferase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

NP_491624.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5549149..5550295 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059223.9 → NP_491624.1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491624.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P91390

Conserved Domains (1) summary

pfam05817
Location:11 → 272

Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II