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    coq-1 Decaprenyl-diphosphate synthase subunit 2 [ Caenorhabditis elegans ]

    Gene ID: 172190, updated on 9-Dec-2024

    Summary

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    Official Symbol
    coq-1
    Official Full Name
    Decaprenyl-diphosphate synthase subunit 2
    Primary source
    WormBase:WBGene00000761
    Locus tag
    CELE_C24A11.9
    See related
    AllianceGenome:WB:WBGene00000761
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable prenyltransferase activity. Involved in ubiquinone biosynthetic process. Predicted to be extrinsic component of mitochondrial inner membrane. Predicted to be part of polyprenyl diphosphate synthase complex. Predicted to be active in mitochondrion. Is expressed in intestine. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 2. Orthologous to human PDSS1 (decaprenyl diphosphate synthase subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See coq-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (5412841..5415629, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene FERM domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Thioredoxin domain-containing protein Neighboring gene Small-subunit processome Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dietary restriction decreases coenzyme Q and ubiquinol potentially via changes in gene expression in the model organism C. elegans. Fischer A, et al. Biofactors, 2015 May 6. PMID 25939481
    2. C. elegans knockouts in ubiquinone biosynthesis genes result in different phenotypes during larval development. Gavilán A, et al. Biofactors, 2005. PMID 16873927
    3. Caenorhabditis elegans ubiquinone biosynthesis genes. Rodríguez-Aguilera JC, et al. Biofactors, 2003. PMID 14695939
    4. Silencing of ubiquinone biosynthesis genes extends life span in Caenorhabditis elegans. Asencio C, et al. FASEB J, 2003 Jun. PMID 12709403
    5. Alignment of the genetic and physical maps in the dpy-5 bli-4 (I) region of C. elegans by the serial cosmid rescue of lethal mutations. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230901

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables prenyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring alkyl or aryl (other than methyl) groups ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in isoprenoid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pheromone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extrinsic component of mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of polyprenyl diphosphate synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Decaprenyl-diphosphate synthase subunit 2
    NP_491588.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5412841..5415629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059187.6 → NP_491588.1  Decaprenyl-diphosphate synthase subunit 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491588.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91093
      Conserved Domains (1) summary
      pfam00348
      Location:80 → 344
      polyprenyl_synt; Polyprenyl synthetase
    Nucleotide Protein
    Heading Accession and Version

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