npp-6 Nuclear Pore complex Protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: npp-6
Official Full Name: Nuclear Pore complex Protein
Primary source: WormBase:WBGene00003792
Locus tag: CELE_F56A3.3
See related: AllianceGenome:WB:WBGene00003792
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be a structural constituent of nuclear pore. Involved in several processes, including nucleus organization; positive regulation of nematode male tail tip morphogenesis; and protein localization to organelle. Located in nuclear membrane. Part of nuclear pore. Human ortholog(s) of this gene implicated in nephrotic syndrome type 19. Orthologous to human NUP160 (nucleoporin 160). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See npp-6 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 15

Sequence:: Chromosome: I; NC_003279.8 (5176830..5182653)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F56A3.3 (e-PCR)
- UniSTS:311848

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macromolecule localization	IEA Inferred from Electronic Annotation more info
involved_in nitrogen compound transport	IEA Inferred from Electronic Annotation more info
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in nucleus organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to nuclear envelope	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear Pore complex Protein

NP_001361963.1

Product from WormBase gene class npp;
Confirmed by transcript evidence

NP_001367609.1

Product from WormBase gene class npp;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5176830..5182653

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380120.2 → NP_001367609.1 Nuclear Pore complex Protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q8T8M4

Conserved Domains (2) summary

pfam11715
Location:3 → 615

Nup160; Nucleoporin Nup120/160

NF035936
Location:1154 → 1214

agg_sub_LPXTH; serine-rich aggregation substance UasX
NM_001374886.3 → NP_001361963.1 Nuclear Pore complex Protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

P91350

Conserved Domains (1) summary

pfam11715
Location:3 → 615

Nup160; Nucleoporin Nup120/160