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    sut-1 SUppressor of Tau pathology [ Caenorhabditis elegans ]

    Gene ID: 173496, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sut-1
    Official Full Name
    SUppressor of Tau pathology
    Primary source
    WormBase:WBGene00020475
    Locus tag
    CELE_T13B5.8
    See related
    AllianceGenome:WB:WBGene00020475
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Located in cytoplasm and nucleus. Is expressed widely. Used to study tauopathy. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sut-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (1121013..1123265, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene LIPaSe related Neighboring gene LIPaSe related Neighboring gene Reverse transcriptase domain-containing protein Neighboring gene TAF (TBP-associated transcription factor) family;TAF6 C-terminal HEAT repeat domain-containing protein;Transcription initiation factor TFIID subunit 6 Neighboring gene Elongator complex protein 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SUT-1 enables tau-induced neurotoxicity in C. elegans. Kraemer BC, et al. Hum Mol Genet, 2007 Aug 15. PMID 17576746
    2. A novel family of C. elegans snRNPs contains proteins associated with trans-splicing. MacMorris M, et al. RNA, 2007 Apr. PMID 17283210, Free PMC Article
    3. An in vivo genetic screen for genes involved in spliced leader trans-splicing indicates a crucial role for continuous de novo spliced leader RNP assembly. Philippe L, et al. Nucleic Acids Res, 2017 Aug 21. PMID 28582530, Free PMC Article
    4. A novel, essential trans-splicing protein connects the nematode SL1 snRNP to the CBC-ARS2 complex. Fasimoye RY, et al. Nucleic Acids Res, 2022 Jul 22. PMID 35736244, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SUppressor of Tau pathology
    NP_001122639.1
    • Product from WormBase gene class sut;
      Confirmed by transcript evidence
    NP_493917.2
    • Product from WormBase gene class sut;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      1121013..1123265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129167.3 → NP_001122639.1  SUppressor of Tau pathology [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122639.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9D649

    2. NM_061516.6 → NP_493917.2  SUppressor of Tau pathology [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493917.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYJ0
    Nucleotide Protein
    Heading Accession and Version

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