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    mcrs-1 FHA domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173133, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mcrs-1
    Official Full Name
    FHA domain-containing protein
    Primary source
    WormBase:WBGene00010420
    Locus tag
    CELE_H28O16.2
    See related
    AllianceGenome:WB:WBGene00010420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G-quadruplex RNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of NSL complex. Orthologous to human MCRS1 (microspherule protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mcrs-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (12647380..12652087, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ATP synthase subunit alpha, mitochondrial Neighboring gene ATP synthase subunit alpha, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
    2. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    3. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G-quadruplex RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Ino80 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MLL1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FHA domain-containing protein
    NP_493201.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      12647380..12652087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060800.9 → NP_493201.3  FHA domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493201.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED60
      Conserved Domains (2) summary
      cd00060
      Location:326 → 410
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam13325
      Location:107 → 249
      MCRS_N; N-terminal region of micro-spherule protein
    Nucleotide Protein
    Heading Accession and Version

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