ttm-5 Putative sphingolipid delta(4)-desaturase/C4-monooxygenase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ttm-5
Official Full Name: Putative sphingolipid delta(4)-desaturase/C4-monooxygenase
Primary source: WormBase:WBGene00013197
Locus tag: CELE_Y54E5A.1
See related: AllianceGenome:WB:WBGene00013197
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable sphingolipid delta-4 desaturase activity. Predicted to be involved in ceramide biosynthetic process. Predicted to be located in membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 18. Orthologous to human DEGS1 (delta 4-desaturase, sphingolipid 1) and DEGS2 (delta 4-desaturase, sphingolipid 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ttm-5 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (14688627..14692144, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y105E8B.g (e-PCR)
- UniSTS:323418

Y54E5A.1 (e-PCR)
- UniSTS:313338

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables sphingolipid C4-monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables sphingolipid delta-4 desaturase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingolipid delta-4 desaturase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sphingolipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Putative sphingolipid delta(4)-desaturase/C4-monooxygenase

NP_493549.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

14688627..14692144 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_061148.4 → NP_493549.1 Putative sphingolipid delta(4)-desaturase/C4-monooxygenase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493549.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EC63

Conserved Domains (3) summary

PLN02579
Location:3 → 316

PLN02579; sphingolipid delta-4 desaturase

cd03508
Location:26 → 315

Delta4-sphingolipid-FADS-like; The Delta4-sphingolipid Fatty Acid Desaturase (Delta4-sphingolipid-FADS)-like CD includes the integral-membrane enzymes, dihydroceramide Delta-4 desaturase, involved in the synthesis of sphingosine; and the human membrane fatty acid (lipid) desaturase ...

pfam08557
Location:6 → 41

Lipid_DES; Sphingolipid Delta4-desaturase (DES)