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    wdr-60 WD Repeat protein [ Caenorhabditis elegans ]

    Gene ID: 175676, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wdr-60
    Official Full Name
    WD Repeat protein
    Primary source
    WormBase:WBGene00016165
    Locus tag
    CELE_C27F2.1
    See related
    AllianceGenome:WB:WBGene00016165
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in intraciliary transport. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in ciliary plasm. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 8 with or without polydactyly. Orthologous to human DYNC2I1 (dynein 2 intermediate chain 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See wdr-60 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    16
    Sequence:
    Chromosome: III; NC_003281.10 (4987209..4991450)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative F-box protein C27F2.7 Neighboring gene PCI domain-containing protein 2 homolog Neighboring gene Transmembrane protein 131 homolog Neighboring gene Guanine nucleotide exchange protein smcr-8 Neighboring gene Coiled-coil domain-containing protein 25 Neighboring gene Transmembrane protein 144 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynein intermediate chains DYCI-1 and WDR-60 have specific functions in Caenorhabditis elegans. Higashida M, et al. Genes Cells, 2023 Feb. PMID 36461782
    2. A gene-centered C. elegans protein-DNA interaction network provides a framework for functional predictions. Fuxman Bass JI, et al. Mol Syst Biol, 2016 Oct 24. PMID 27777270, Free PMC Article
    3. WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing. De-Castro ARG, et al. J Cell Biol, 2022 Jan 3. PMID 34739033, Free PMC Article
    4. Functional genomics of the cilium, a sensory organelle. Blacque OE, et al. Curr Biol, 2005 May 24. PMID 15916950
    5. The relationship between intraflagellar transport and upstream protein trafficking pathways and macrocyclic lactone resistance in Caenorhabditis elegans. Brinzer RA, et al. G3 (Bethesda), 2024 Mar 6. PMID 38227795, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynein intermediate chains DYCI-1 and WDR-60 have specific functions in Caenorhabditis elegans.
      Title: Dynein intermediate chains DYCI-1 and WDR-60 have specific functions in Caenorhabditis elegans.
    2. WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing.
      Title: WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WD Repeat protein
    NP_001367569.1
    • Product from WormBase gene class wdr;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4987209..4991450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381848.1 → NP_001367569.1  WD Repeat protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18263
    Nucleotide Protein
    Heading Accession and Version

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