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    M02B1.3 TLC domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178236, updated on 9-Dec-2024

    Summary

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    Official Symbol
    M02B1.3
    Official Full Name
    TLC domain-containing protein
    Primary source
    WormBase:WBGene00010828
    Locus tag
    CELE_M02B1.3
    See related
    AllianceGenome:WB:WBGene00010828
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Located in plasma membrane. Orthologous to human TLCD1 (TLC domain containing 1) and TLCD2 (TLC domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See M02B1.3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (12836508..12840411)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Cytohesin Ubiquitin Protein Inducing domain-containing protein;FERM domain-containing protein Neighboring gene Bax inhibitor-1 family protein Neighboring gene transcellular chaperone signaling (x)cross tissue Neighboring gene UDP-galactose/UDP-N-acetylglucosamine transporter srf-3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in membrane assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of membrane lipid distribution IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TLC domain-containing protein
    NP_001294011.1
    • Confirmed by transcript evidence
    NP_502445.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12836508..12840411
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307082.3 → NP_001294011.1  TLC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294011.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AD30
      Conserved Domains (1) summary
      smart00724
      Location:85 → 285
      TLC; TRAM, LAG1 and CLN8 homology domains

    2. NM_070044.7 → NP_502445.1  TLC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502445.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93892
      Conserved Domains (1) summary
      smart00724
      Location:85 → 285
      TLC; TRAM, LAG1 and CLN8 homology domains
    Nucleotide Protein
    Heading Accession and Version

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