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    Emp1 epithelial membrane protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 13730, updated on 13-Jan-2025

    Summary

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    Official Symbol
    Emp1provided by MGI
    Official Full Name
    epithelial membrane protein 1provided by MGI
    Primary source
    MGI:MGI:107941
    See related
    Ensembl:ENSMUSG00000030208 AllianceGenome:MGI:107941
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TMP; I-8-09
    Summary
    Predicted to be involved in apoptotic process and bleb assembly. Predicted to be active in plasma membrane. Is expressed in several structures, including eye; heart valve; and nervous system. Orthologous to human EMP1 (epithelial membrane protein 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in limb E14.5 (RPKM 93.5), colon adult (RPKM 49.7) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Emp1 in Genome Data Viewer
    Location:
    6 G1; 6 66.25 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (135339548..135360171)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (135362550..135383173)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene dynein light chain Tctex-type 1, pseuodogene 1 Neighboring gene predicted gene, 52922 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:135400637-135400820 Neighboring gene predicted gene, 50630 Neighboring gene RIKEN cDNA 4930425L21 gene Neighboring gene STARR-seq mESC enhancer starr_17574

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Metastatic recurrence in colorectal cancer arises from residual EMP1(+) cells. Cañellas-Socias A, et al. Nature, 2022 Nov. PMID 36352230, Free PMC Article
    2. The tmp gene, encoding a membrane protein, is a c-Myc target with a tumorigenic activity. Ben-Porath I, et al. Mol Cell Biol, 1999 May. PMID 10207076, Free PMC Article
    3. Embryonic expression of epithelial membrane protein 1 in early neurons. Wulf P, et al. Brain Res Dev Brain Res, 1999 Sep 6. PMID 10521561
    4. Epithelial membrane protein-1 is a biomarker of gefitinib resistance. Jain A, et al. Proc Natl Acad Sci U S A, 2005 Aug 16. PMID 16087880, Free PMC Article
    5. Epithelial membrane protein-1, peripheral myelin protein 22, and lens membrane protein 20 define a novel gene family. Taylor V, et al. J Biol Chem, 1995 Dec 1. PMID 7499407

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bleb assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bleb assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    epithelial membrane protein 1
    Names
    EMP-1
    tumor-associated membrane protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001288627.1 → NP_001275556.1  epithelial membrane protein 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      BC050899
      Consensus CDS
      CCDS20647.1
      UniProtKB/Swiss-Prot
      P47801
      UniProtKB/TrEMBL
      Q3UXM2, Q4FK43
      Related
      ENSMUSP00000107538.2, ENSMUST00000111907.2
      Conserved Domains (1) summary
      pfam00822
      Location:1 → 154
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    2. NM_001288628.1 → NP_001275557.1  epithelial membrane protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon compared to variant 1, which causes translation initiation at an alternate start codon. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC122820, AK159752, BC050899
      UniProtKB/TrEMBL
      Q05BR0, Q3UXM2
      Conserved Domains (1) summary
      cl21598
      Location:1 → 126
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    3. NM_010128.4 → NP_034258.1  epithelial membrane protein 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC122820
      Consensus CDS
      CCDS20647.1
      UniProtKB/Swiss-Prot
      P47801
      UniProtKB/TrEMBL
      Q3UXM2, Q4FK43
      Related
      ENSMUSP00000032330.10, ENSMUST00000032330.16
      Conserved Domains (1) summary
      pfam00822
      Location:1 → 154
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      135339548..135360171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505502.1 → XP_006505565.1  epithelial membrane protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P47801
      UniProtKB/TrEMBL
      Q3UXM2, Q4FK43
      Related
      ENSMUSP00000145069.2, ENSMUST00000205156.3
      Conserved Domains (1) summary
      pfam00822
      Location:1 → 154
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47801.2 GenPept UniProtKB/Swiss-Prot:P47801

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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