fat-1 Omega-3 fatty acid desaturase fat-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: fat-1
Official Full Name: Omega-3 fatty acid desaturase fat-1
Primary source: WormBase:WBGene00001393
Locus tag: CELE_Y67H2A.8
See related: AllianceGenome:WB:WBGene00001393
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable oxidoreductase activity. Involved in positive regulation of locomotion and unsaturated fatty acid biosynthetic process. Predicted to be located in membrane. Is expressed in intestine; nerve ring; and touch receptor neurons. Used to study alcohol use disorder. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See fat-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 3

Sequence:: Chromosome: IV; NC_003282.8 (13315644..13318811)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these findings suggest that the iFat1 transgenic mouse may be a promising tool to help elucidate the temporal effects through which n-3 PUFA impacts health related outcomes.
Title: The iFat1 transgene permits conditional endogenous n-3 PUFA enrichment both in vitro and in vivo.
Endogenous synthesis of n-3 PUFA in the fat-1 transgenic mouse attains similar kidney n-3 PUFA composition and eicosanoid levels as compared to fish oil feeding.
Title: Endogenous synthesis of n-3 PUFA modifies fatty acid composition of kidney phospholipids and eicosanoid levels in the fat-1 mouse.
Fat-1 transgene expression suppresses CD4+ T-cell activation and differentiation in spleen, and reduces inflammatory cytokines and eotaxin in bronchoalveolar lavage and lung tissues of mice.
Title: Effects of n-3 PUFA on the CD4⁺ type 2 helper T-cell-mediated immune responses in Fat-1 mice.
our results indicate that functional fat-1 and topically applied DHA potentiate cellular defense against UVB-induced skin inflammation and photocarcinogenesis through elevated activation of Nrf2 and upregulation of cytoprotective gene expression.
Title: Endogenous ω-3 Fatty Acid Production by fat-1 Transgene and Topically Applied Docosahexaenoic Acid Protect against UVB-induced Mouse Skin Carcinogenesis.
Balanced diet-fed Fat-1 mice are able to preserve in part the soleus muscle mass, absolute isotonic force and cross-sectional area of the soleus muscle in a disuse condition.
Title: Balanced Diet-Fed Fat-1 Transgenic Mice Exhibit Lower Hindlimb Suspension-Induced Soleus Muscle Atrophy.
The protection of fat-1 mice from UVB-induced skin inflammation was associated with decreased phosphorylation of STAT3. Moreover, UVB-induced apoptosis was attenuated in fat-1 mouse skin.
Title: Amelioration of UVB-induced oxidative stress and inflammation in fat-1 transgenic mouse skin.
Fat-1 transgenic mice express fat-1 from Caenorhabditis elegans. The kidneys of fat-1 mice showed better renal cell survival, renal function, and pathological damage than those of wt mice after Ischemia-Reperfusion Renal Injury.
Title: High Endogenous Accumulation of ω-3 Polyunsaturated Fatty Acids Protect against Ischemia-Reperfusion Renal Injury through AMPK-Mediated Autophagy in Fat-1 Mice.
Results suggest that endogenous omega-3 polyunsaturated fatty acids in APP/fat-1 mice could efficiently alleviate cognitive impairment and apathetic symptom comparing to their APP littermates. Neuronal survival and astrocytic activation were also observed ameliorated in APP mice after expression of fat-1 gene activated the NF-kappaB/Bcl-2 antiapoptotic pathway and inhibited the inflammatory response.
Title: Enriched endogenous n-3 polyunsaturated fatty acids alleviate cognitive and behavioral deficits in a mice model of Alzheimer's disease.
In the present study, endogenously increased levels of n-3 polyunsaturated fatty acids in the tumor tissues of omega3 fatty acid desaturase (fat1) transgenic mice was associated with a reduction in the growth rate of melanoma xenografts.
Title: Endogenously synthesized n-3 fatty acids in fat-1 transgenic mice prevent melanoma progression by increasing E-cadherin expression and inhibiting β-catenin signaling.
data suggest that the central n-3 PUFA increase observed in Fat-1 transgenic mice modulated the brain innate immune system activity .
Title: Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y67H2B.a (e-PCR)
- UniSTS:323991

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in unsaturated fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in unsaturated fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in unsaturated fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Omega-3 fatty acid desaturase fat-1

NP_001023560.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

13315644..13318811

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028389.5 → NP_001023560.1 Omega-3 fatty acid desaturase fat-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023560.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21056, Q9NEQ0

Conserved Domains (2) summary

COG3239
Location:52 → 387

DesA; Fatty acid desaturase [Lipid transport and metabolism]

cd03507
Location:70 → 338

Delta12-FADS-like; The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of ...