hprt-1 Hypoxanthine phosphoribosyltransferase [Caenorhabditis elegans] - Gene

Summary

Official Symbol: hprt-1
Official Full Name: Hypoxanthine phosphoribosyltransferase
Primary source: WormBase:WBGene00013690
Locus tag: CELE_Y105E8B.5
See related: AllianceGenome:WB:WBGene00013690
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables identical protein binding activity. Predicted to be involved in hypoxanthine metabolic process and purine-containing compound salvage. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in HRPT-related hyperuricemia and Lesch-Nyhan syndrome. Orthologous to several human genes including PRTFDC1 (phosphoribosyl transferase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables guanine phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hypoxanthine phosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hypoxanthine phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables magnesium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GMP salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in IMP salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in IMP salvage	IEA Inferred from Electronic Annotation more info
involved_in guanine salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in hypoxanthine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in purine ribonucleoside salvage	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

NP_493545.1

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The following sections contain reference sequences that belong to a specific genome build. Explain